EFEK PERASAN KERING KULIT NANAS (Ananas comosus (L). Merr) TERHADAP WAKTU PERDARAHAN DAN PEMBEKUAN DARAH PADA TIKUS PUTIH JANTAN (Rattus norvegicus)

Lupita, Veronica Bella (2014) EFEK PERASAN KERING KULIT NANAS (Ananas comosus (L). Merr) TERHADAP WAKTU PERDARAHAN DAN PEMBEKUAN DARAH PADA TIKUS PUTIH JANTAN (Rattus norvegicus). Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Pineapple has a peel that contains bromelain enzyme which is useful as platelet antiagregation. This study was aimed to determine the effect of pineapple peel dried juice on bleeding and clotting time extention, and to know the most effective dose in prolonging bleeding time and blood clotting. This study includes the determination of plants, drying of pineapple peel, the identification of the chemical contents, and test of bleeding and clotting time. This study used 5 treatment groups. The group was divided into treatment groups with pineapple peel dried juice variation dose of 28 mg/200 g BW, 56 mg/200 g BW, and 112 mg/200 g BW, positive control group (acetosal 3.7 mg/200 g BW), and negative control group (distilled water). The identification results showed chemical constituents of bromelain enzyme compounds, flavonoids, and saponins. The test results showed that platelets antiagregation from pineapple peel dried juice which was administered orally could prolong the bleeding time and blood clotting on white male rats. Pineapple peel dried juice with a dose of 112 mg/200 g BW gave the best effect to the extension of bleeding and clotting time with an average increase in bleeding time of 150 seconds and an increase in clotting time of 105 seconds. Keywords : acetosal, pineapple peel, bleeding time, clotting time

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	acetosal, pineapple peel, bleeding time, clotting time
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Tifany Nur Arfiana
Date Deposited:	20 Feb 2020 02:51
Last Modified:	20 Feb 2020 02:51
URI:	http://repo.setiabudi.ac.id/id/eprint/2875

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