EFEK FRAKSI ETIL ASETAT DAUN SELIGI (Phyllanthus buxifolius Muell, Arg.) TERHADAP KADAR BILIRUBIN TOTAL SERUM DAN NEKROSIS SEL HATI TIKUS JANTAN GALUR WISTAR

Ramdini, Dwi Aulia (2013) EFEK FRAKSI ETIL ASETAT DAUN SELIGI (Phyllanthus buxifolius Muell, Arg.) TERHADAP KADAR BILIRUBIN TOTAL SERUM DAN NEKROSIS SEL HATI TIKUS JANTAN GALUR WISTAR. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Leaves of Phyllanthus buxifolius Muell.Arg. contain antioxidant compounds such as flavonoids, alkaloids, tannins, terpenoids and polyphenols. Antioxidant compounds that are important in protecting the body from free radicals. This study was conducted to determine the effect of ethyl acetate fraction of seligi leaves againts serum total bilirubin levels and liver cell necrosis wistar male rats. This study used thirty rats were divided into 6 groups. Groups I as normal group were given food and water. Group II as negative controls were given paracetamol 500 mg/200 g BW. Group III as a positif control were given curcuma®. Group IV,V and VI as treatment of test fraction 5 mg/200 g BW, 10 mg/200 g BW and 15 mg/200 g BW. The treatment was given for 7 days, on day 5 in all groups except paracetamol induced normal controls. All group on days 0th, 4th and 7th calculate levels of serum total bilirubin. On 7th days all animals in each group were sacrificed. Rat liver was taken for histopathology preparation is done by calculating the percentage of liver cell necrosis. Both results were analyzed by One Way Anova test and continued with Tukey HSD test. The results showed that the fraction of dose 5 mg/200g BW, 10 mg/200 g BW, 15 mg/200 g BW was able to inhibited the increase in serum bilirubin levels and inhibetd liver cell necrosis wistar male rats. 10 mg/200 g BW dose fraction was effective in inhibited increase serum total bilirubin levels and necrosis of liver cells wistar male rats. Keyword : Seligi leaves, levels serum total bilirubin, cell

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	Seligi leaves, levels serum total bilirubin, cell
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	magdalena kartika ningsih
Date Deposited:	21 Feb 2020 03:43
Last Modified:	21 Feb 2020 03:43
URI:	http://repo.setiabudi.ac.id/id/eprint/2943

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