Eko, Fridolina (2013) EFEK PEMBERIAN EKSTRAK ETANOLIK HERBA PUTRI MALU (Mimosa pudica Linn.) PADA MODEL ASMA ALERGI DENGAN PARAMETER HITUNG SEL MAST BRONKUS PADA MENCIT BALB/C. Skripsi thesis, Universitas Setia Budi Surakarta.
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Abstract
Asthma is a chronical inflammation problem in respiratory system. Sensitive plants herb has the biology activity on the inflammation reaction of asthma disease. The aim of this research was to know the anti-asthma effect of Sensitive plants herb extract based on the decreasing number of cell mast bronchial on mice Balb / c which was sensitized to ovalbumin. Sensitive plants macerated by using 70% ethanol liquid. The tested animals were males Balb / c that were divided into 5 groups. First group was given Telfast® as the positive control, second group was given CMC 0.5% liquid of sensitive plants with the dosagee of 1.95 mg/20 g BB, 3.9 mg/20 g BB, 7.8 mg/20 g BB everyday for 27 days. At day 0 (after 7 days of treatment) and day 14, the tested animals were sensitized by using ovalbumin in Al (OH)3 intraperitoneally and at day 21, 23, 25, and 27 by using aerosol ovalbumin sensitization. At day 28, the tested animals were killed and their tissue of bronchus were taken to be made blood smear with Aniline painting. The measurement of cell mast bronchus number was done by observing the 10x40 magnification counted into 3 overview of each mencit. One-way ANOVA statistical test was used to know whether there was or there was no significant decreasing of cell mast among five treatment groups and continued with Tukey HSD test after the data was assured to be homogeneous. The results showed that administration of herbal extracts sensitive plants has the effect of decreasing the number of parameters antiasthma through bronchial mast cells when compared with negative controls. Herbal extract dose sensitive plants 3,9 mg/20g BB mice are the most effective dose in reducing the number of bronchial mast cells Balb / C male. Keywords: Herb Sensitive plants (mimosa pudica Linn), mast cells, allergic asthma, bronchial
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | Herb Sensitive plants (mimosa pudica Linn), mast cells, allergic asthma, bronchial |
| Subjects: | Q Science > QD Chemistry R Medicine > RS Pharmacy and materia medica S Agriculture > S Agriculture (General) |
| Divisions: | Fakultas Farmasi > Prodi S1 Farmasi |
| Depositing User: | magdalena kartika ningsih |
| Date Deposited: | 21 Feb 2020 03:42 |
| Last Modified: | 21 Feb 2020 03:42 |
| URI: | http://repo.setiabudi.ac.id/id/eprint/2969 |
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