Kristiana, Ririn (2013) FORMULASI DAN EVALUASI BUKAL MUCOADHESIF PATCH SALBUTAMOL SULFAT DENGAN VARIASI KADAR POLIVINYL PIROLIDON K-30 DAN NATRIUM KARBOKSIMETIL SELULOSA SEBAGAI MATRIKS. Skripsi thesis, Universitas Setia Budi Surakarta.
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01. INTISARI.pdf Download (14kB) |
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02. HALAMAN JUDUL - BAB I.pdf Download (388kB) |
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06. BAB V - LAMPIRAN.pdf Download (1MB) |
Abstract
Mucoadhesive buccal patches of salbutamol sulfate for systemic administration of the oral cavity has been developed with the difference consentration of CMC-Na and PVP K-30. CMC-Na is used to prevent the tissue attachment as well as to localize and modify drug release kinetics of the mucous membranes and PVP K-30 can increase the release of the drug and the swelling of the polymers, increasing elasticity and swelling index of the patches. This study consist of 4 formulas with the ratio of CMC-Na and PVP K-30 were 10:0; 9:1; 8:2; 7:3 and control. Formulations were evaluated at various parameters such as weight uniformity, folding endurance, surface pH, swelling index, content uniformity and in vitro drug release in phosphate buffer medium pH 6.8 using type 2 apparatus at 37 ° C USP XXII. The amount of salbutamol sulphate in the solution was measured spectrophotometrically at maximum wavelength 276,2 nm. The results of weight uniformity from all formulas were <5%, folding endurance were >300 times, surface were pH 6-7, the results of the swelling index from 4th formula was reached 320.97%, the drug release followed zero-order release kinetics, by Higuchi model following the diffusion mechanism that is reinforced by the value of n at-Peppas korsmeyer of each formula <0.45 so that the mechanisms that contribute was the Fickian diffusion. Keywords : formulation, buccal mucoadhesive patches, salbutamol sulphate, CMC-Na, PVP K-30
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | formulation, buccal mucoadhesive patches, salbutamol sulphate, CMC-Na, PVP K-30 |
| Subjects: | R Medicine > RS Pharmacy and materia medica |
| Divisions: | Fakultas Farmasi > Prodi S1 Farmasi |
| Depositing User: | B Supri Yadi |
| Date Deposited: | 04 Nov 2019 03:50 |
| Last Modified: | 04 Nov 2019 03:50 |
| URI: | http://repo.setiabudi.ac.id/id/eprint/3032 |
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