Suyadi, Suyadi (2013) SINTESIS SENYAWA (4-AMINOPHENYL)-3-(FURAN-2-YL)PROP-2-EN1-ONE MENGGUNAKAN SENYAWA PEMULA FURFURAL DAN pAMINOASETOFENON DALAM PELARUT ETANOL DENGAN KATALIS BASA. Skripsi thesis, Universitas Setia Budi Surakarta.
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Abstract
Chalcone is the intermediate compound of the synthesis in of flavonoid derivative through a certain mechanism path. Chalcon has various biological activities such as antioxidant, antitumor, antibacterial, antiviral, anti-inflammatory, antifungal, and antimicrobial. This study aims to synthesize the compounds curcumin analogues (4aminophenyl)-3-(furan-2-yl)prop-2-en-1-one based on mechanism Claissen-Schmidt condensation reaction, using a furfural compounds is starting material with paminoasetofenon using ethanol as the solvents with alkaline catalyst at room temperature. Synthesis of (4-aminophenyl)-3-(furan-2-yl)prop-2-en-1-one was based on mechanism Claissen-Schmidt condensation reaction. Furfural and p-aminoasetofenon in ethanol solvent with alkaline catalyst were stirred for 3 hours, at room temperatur (270C) then ad 50 mL of distilled water, was added and then the mixture was cooled to stand for 30 minutes. Then the precipitate was filtered with a filter buchner happen, then washed until neutral (pH 7) with wind dried sediment cold distilled water followed by recrystallization with ethanol. Analysis of the purity of the synthesized compounds was conducted by melting point, TLC test, and gas chromatography. Analysis of structure elucidation was done by infrared spectrophotometer, mass spectrophotometers as need as UV spectrophotometry. Melting point analysis with test compounds melt at a temperature of 104 ° C-115 ° C, test developers TLC with solvent system: chloroform (3:1) Rf = 0.78. n-hexane: ethyl acetate (1:3), Rf = 0.84. n-hexane: ethyl acetate (3:1), Rf = 0.4 shows the results of the spot, and with a purity of 93.42% indicates chromatography. Infrared spectrophotometer analysis showed a shift in the carbonyl group C = O to lower frequency at 1635.64 cm-1 from 1640 to 1840 cm-1 frequency. Spesific mass spectrophotometer analysis showed the molecular weight of the target compound 213. UV spectrophotometry compounds synthesized appeared at a wavelength of 245 nm and 355 nm. The result showed that the compounds chalcone analog (4-aminophenyl)-3-(furan2-yl)prop-2-en-1-one successfully synthesized with % yield of 87.23%, Recovery 48.48% and have elucidated the chemical structure in line with estimates by 93.42% purity. Keywords: synthesis, recrystallization, (4-aminophenyl)-3-(furan-2-yl)prop-2-en-1- one, base catalyst, and condensation.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | synthesis, recrystallization, (4-aminophenyl)-3-(furan-2-yl)prop-2-en-1- one, base catalyst, and condensation. |
| Subjects: | R Medicine > RS Pharmacy and materia medica |
| Divisions: | Fakultas Farmasi > Prodi S1 Farmasi |
| Depositing User: | B Supri Yadi |
| Date Deposited: | 22 Nov 2019 03:43 |
| Last Modified: | 22 Nov 2019 03:43 |
| URI: | http://repo.setiabudi.ac.id/id/eprint/3060 |
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