OPTIMASI PROPORSI CAMPURAN POLISORBAT 80 DAN SORBITAN 80 PADA KRIM LENDIR BEKICOT (Achatina fulica Ferr) SEBAGAI ANTIBAKTERI SECARA SIMPLEX LATTICE DESIGN

Febrilia, Yeni (2013) OPTIMASI PROPORSI CAMPURAN POLISORBAT 80 DAN SORBITAN 80 PADA KRIM LENDIR BEKICOT (Achatina fulica Ferr) SEBAGAI ANTIBAKTERI SECARA SIMPLEX LATTICE DESIGN. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

The escargot (Achatina fulica ferr.) mucus capsule is one traditional medicine used (by the people) to cure new wound, menstruation pain, corneitis, toothache, heart disease, etc. Escargot mucus contained antimicrobial peptide functioning in covering wound. According to Iskandar (2012), escargot mucus at 20% concentration had antibacterial activity against Staphylococcus aureus ACTCC 25923. The use of escargot mucus directly was considered as cumbersome, so that a cream preparation is made. This research aimed to get the optimum formula of escargot mucus cream using polisorbat 80 and sorbitan 80 surfactant based on Design Expert method. The escargot mucus cream was made of three formulas based on Design Expert. The cream produced was tested for its physical properties including organoleptic, viscosity, spreadability, viscosity shift, and antibacterial activity with diffusion method. The optimum formulation obtained using Design Expert 8.0.6.1 was made and tested for its physical properties for 4 weeks; the result of cream’s physical property test obtained was then analyzed statistically using t-test and to find out the variance of each formula, one-way anava test statistical analysis and t-tukey test could be carried out at significance level of 95%. The result of research on the optimum formulation of escargot mucus cream was obtained at the 4.635% polisorbat 80 and 2.365% sorbitan 80 proportion. The physical response of optimum formula from the prediction and experiment result showed no significant difference. The optimum formulation cream could be an antibacterial activity of 2.7 cm. Keywords:Escargot (Achatina fulica ferr.) mucus, Simplex Lattice Design, cream, polisorbat 80, sorbitan 80

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	Escargot (Achatina fulica ferr.) mucus, Simplex Lattice Design, cream, polisorbat 80, sorbitan 80
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	B Supri Yadi
Date Deposited:	20 Nov 2019 03:47
Last Modified:	20 Nov 2019 03:47
URI:	http://repo.setiabudi.ac.id/id/eprint/3073

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