Gunawan, Agus (2019) OPTIMASI FORMULA SHAMPO EKSTRAK LAPISAN PUTIH KULIT BUAH SEMANGKA (Citrullus vulgaris, Schrad.) DENGAN KOMBINASI HPMC DAN NLS SERTA UJI AKTIVITASNYA PADA JAMUR Pityrosporumovale. Tesis thesis, Fakultas Farmasi.
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Abstract
The white skin layer water melon rind has been known have a antifungal activity. One of the diseases caused by fungi is dandruff. This study aims to make a preparation of Shampoo of white layer of watermelon rind extract which has good physical quality with a combination of Hydroxy Propyl Methyl Cellulose (HPMC) and sarcosyl; determine the effect of variations in the combination of Hydroxy Propyl Methyl Sellulose and sarcosyl on the physical properties and stability of the preparation shampoo of extract etanolic white layer of watermelon rind. Determination of the formula with simplex lattice design using Design Expert® software as many as 13 formulas. Evaluation included physical properties (organoleptic, viscosity, preparation shampo extract etanolic white layer of watermelon peel type weight, surface tension, foam height, pH) and stability of the preparation shampo extract etanolic white layer of watermelon skin. The optimum formula was tested for physical characteristics compared to the predicted results of the Design Expert® software. The shampoo formula produced was tested for its activity on Pityrosporum ovale and tested its safety on rabbit's skin and eyes. The results showed that HPMC and sodium lauroil sarcosinate had an influences on the physical properties of the preparation shampo. Increasing the sarcosyl concentration affects the foam height of the shampoo and HPMC has a significant effect on the specific gravity, viscosity, surface tension and stability of foam. The optimum physical quality in 0.725% HPMC, and 1.275% sarcosyl. Watermelon skin extract white shampoo has anti Pityrosporum ovale activity with an effective concentration of 40% with inhibition zona diameter is 39,00 mm. Keywords: white layer of watermelon skin, ethanolic extract, Hydroxy Propyl Methyl Cellulose, sarcosyl, Pityrosporum ovale
| Item Type: | Thesis (Tesis) |
|---|---|
| Uncontrolled Keywords: | white layer of watermelon skin, ethanolic extract, Hydroxy Propyl Methyl Cellulose, sarcosyl, Pityrosporum ovale |
| Subjects: | R Medicine > R Medicine (General) |
| Divisions: | Fakultas Farmasi > Prodi S2 Farmasi |
| Depositing User: | Mrs NOVI HANDAYANI |
| Date Deposited: | 15 Oct 2019 08:41 |
| Last Modified: | 15 Oct 2019 08:41 |
| URI: | http://repo.setiabudi.ac.id/id/eprint/3392 |
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