UJI AKTIVITAS ANTIDIABETES DAN IDENTIFIKASI SENYAWA BIJI OYONG (Luffa acutangula (L.) Roxb) SERTA PENGARUHNYA TERHADAP JUMLAH GLUCOSE TRANSPORTER 4 MEMBRAN JARINGAN OTOT PADA TIKUS RESISTENSI INSULIN

Rianto, Benny (2019) UJI AKTIVITAS ANTIDIABETES DAN IDENTIFIKASI SENYAWA BIJI OYONG (Luffa acutangula (L.) Roxb) SERTA PENGARUHNYA TERHADAP JUMLAH GLUCOSE TRANSPORTER 4 MEMBRAN JARINGAN OTOT PADA TIKUS RESISTENSI INSULIN. Tesis thesis, Fakultas Farmasi.

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Abstract

Oyong (Luffa acutangula (L.) Roxb) was a plant that can be used to treat type II Diabetes Mellitus (DM). The oyong used was the seeds. This study aims to determine the antidiabetic activity and identification of extract and fractions of oyong seeds based on a decrease in blood glucose levels and an increase in the amount of glucose transporter protein 4 (GLUT-4) membranes muscle tissue on type II DM rats model of insulin resistance. This study used 40 experimental animals, divided into 8 groups: normal, positive control (metformin 45 mg / kgBW), negative control (CMC 0.5%), ethanol extract of oyong seeds 100 and 200 mg / kgBW, n-hexane fraction 84.82 mg / kgBW, ethyl acetate fraction 34.44 mg / kgBW, water fraction 80.74 mg / kgBW. Rats induced insulin resistance by giving a high fat diet (HFD) and fructose for 60 days and injected (i.p) low-dose STZ 30 mg / kgBW on the 30th day and 44th day. Blood glucose levels were measured at 69, 76, 83 and 90th days after treatment. The most active fraction was followed by immunohistochemistry and isolation. The ethyl acetate fraction of oyong seeds as the most active fraction has a percentage of antihyperglycemic activity was 42.20% and the percentage of the activity of increasing GLUT-4 level membrane was 42.07%. Isolation and identification of ethyl acetate fraction was estimated to contain chemical compound apigenin-6,8-di-C-glucoside (Vicenin-2). Keywords : Oyong seeds, antidiabetic, insulin resistance, GLUT-4, identification

Item Type:	Thesis (Tesis)
Uncontrolled Keywords:	Oyong seeds, antidiabetic, insulin resistance, GLUT-4, identification.
Subjects:	R Medicine > R Medicine (General)
Divisions:	Fakultas Farmasi > Prodi S2 Farmasi
Depositing User:	Mrs NOVI HANDAYANI
Date Deposited:	01 Nov 2019 07:40
Last Modified:	01 Nov 2019 07:40
URI:	http://repo.setiabudi.ac.id/id/eprint/3411

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