OPTIMASI FORMULA SABUN PADAT ANTIBAKTERI EKSTRAK ETANOL BUAH PARE (Momordica charantia L.) DENGAN VARIASI VIRGIN COCONUT OIL (VCO) DAN COCOAMIDOPROPYL BETAINE

Mardiyanti, Devi (2019) OPTIMASI FORMULA SABUN PADAT ANTIBAKTERI EKSTRAK ETANOL BUAH PARE (Momordica charantia L.) DENGAN VARIASI VIRGIN COCONUT OIL (VCO) DAN COCOAMIDOPROPYL BETAINE. Tesis thesis, Fakultas Farmasi.

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Abstract

One plant that has the potential as antibacterial is bitter melon fruit. VCO is easily absorbed by the skin so that the skin becomes moist. Betaine is used in making soap to produce abundant foam. Optimization of VCO and betaine aims to get moist soap, produce a lot of foam, and not irritate the skin. The purpose of this study was to optimize the formula for solid soap of bitter melon extract with variations of VCO and betaine to produce good soap, not irritate the skin, and have antibacterial activity against S. aureus. Optimization using the factorial Design Expert version 10 software design was carried out on physical properties parameters including soap hardness, foam height, and pH of the soap. Antibacterial activity test of the diffusion method on S. aureus bacteria used 0.5% concentration of bitter melon extract. The optimum formula was tested for irritation using the draize score method using 5 male rabbits with observations for 24, 48 and 72 hours. The optimization results produced VCO (7.5 grams) and betaine (6.9 grams) with hardness criteria (2.66 kg), foam height (8.01 cm), and pH (9.13). The optimum T-test formula analysis results of observations and predictions were not significantly different from the p-value> 0.05. The optimum formula has antibacterial activity with inhibition zone diameter of 11.56 ± 2.01 mm, and has an irritation index of 0.0-0.4 (no harm and is safe for the skin). Keywords: Staphylococcus aureus, VCO, betaine, draize, formulation, bitter melon

Item Type:	Thesis (Tesis)
Uncontrolled Keywords:	Staphylococcus aureus, VCO, betaine, draize, formulation, bitter melon
Subjects:	R Medicine > R Medicine (General)
Divisions:	Fakultas Farmasi > Prodi S2 Farmasi
Depositing User:	Mrs NOVI HANDAYANI
Date Deposited:	01 Nov 2019 07:40
Last Modified:	17 Sep 2020 07:31
URI:	http://repo.setiabudi.ac.id/id/eprint/3414

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