EFEK EKSTRAK BATANG BROTOWALI (Tinospora crispa L. Miers) PADA MODEL UJI TIKUS HIPERGLIKEMIA KOMORBID HIPERLIPIDEMIA

Wijaya, Hasty Martha (2019) EFEK EKSTRAK BATANG BROTOWALI (Tinospora crispa L. Miers) PADA MODEL UJI TIKUS HIPERGLIKEMIA KOMORBID HIPERLIPIDEMIA. Tesis thesis, Fakultas Farmasi.

	Text BAB 2.pdf Restricted to Registered users only Download (666kB) | Request a copy
	Text BAB 3.pdf Restricted to Registered users only Download (247kB) | Request a copy
	Text BAB 4.pdf Restricted to Registered users only Download (1MB) | Request a copy
	Text BAB 5.pdf Restricted to Registered users only Download (85kB) | Request a copy
	Text BAB 6-LAMPIRAN.pdf Restricted to Registered users only Download (2MB) | Request a copy
	Text COVER-BAB 1.pdf Download (554kB)
	Text INTISARI-ABSTRAK.pdf Download (13kB)
	Text LEMBAR PUBLIKASI.pdf Download (305kB)

Abstract

Hyperglycemia causes impaired carbohydrate and fat metabolism. Impaired insulin secretion occurs due to the presence of free radicals due to induction. Hyperglycemic causes lipid metabolism abnormalities characterized by changes in lipid profile in the form of increased levels of LDL, triglycerides, total cholesterol and decreased levels of HDL. This study aims to determine the effect of brotowali stem extracts on decreasing blood glucose levels and improving lipid profile. This study used 7 groups of mice, and each group induced a high fat diet (HFD) and propylthiouracil (PTU) for 21 days followed by administration of Streptozotocin-nicotinamide (45/110 mg/kg) for 3 days, except in group 1 namely normal control group. Group 2 as negative group (HFD + DM), group 3 and 4 as positive control (Metfomin and Simvastatin), groups 5, 6 and 7 were each given a dose variation of brotowali stem extract 100 mg / kgBB, 200 mg / kgBB and 400 mg / kgBB. The test material was given orally for 14 days, then seen an increase in body weight of rats, a decrease in blood glucose levels, and improvement in lipid profile, as well as an improvement in the histopathological profile of the pancreas and liver with staining of Hemactocillin-Eosin (HE). These results indicate that dose variation brotowali stem extract can lower blood glucose levels. In the improvement of lipid profiles all extracts dose variation also able to improve the lipid profile, but a dose of 400 mg of the extract is the most effective dose in lowering levels of LDL, raise HDL cholesterol levels and decreased the levels of triglycerides. In the improvement of the pancreas and liver histopathology profile showed that the administration of extracts variation is able to repair the pancreas and liver. Keyword : Tinospora crispa L. Miers, hyperglicemic, hyperlipidemia, HFD, PTU, Streptozotocin-nikotinamid, metformin, simvastatin

Item Type:	Thesis (Tesis)
Uncontrolled Keywords:	Tinospora crispa L. Miers, hyperglicemic, hyperlipidemia, HFD, PTU, Streptozotocin-nikotinamid, metformin, simvastatin
Subjects:	R Medicine > R Medicine (General)
Divisions:	Fakultas Farmasi > Prodi S2 Farmasi
Depositing User:	Mrs NOVI HANDAYANI
Date Deposited:	01 Nov 2019 07:34
Last Modified:	01 Nov 2019 07:34
URI:	http://repo.setiabudi.ac.id/id/eprint/3422

Actions (login required)

View Item