AKTIVITAS ANTIHIPERGLIKEMI, PERBAIKAN FUNGSI DAN REGENERASI GINJAL FRAKSI-FRAKSI EKSTRAK ETANOL DAUN AFRIKA (Vernonia amygdalina Delile)PADA TIKUS DIABETES NEFROPATI

MESAK, IVAN JUNIUS (2019) AKTIVITAS ANTIHIPERGLIKEMI, PERBAIKAN FUNGSI DAN REGENERASI GINJAL FRAKSI-FRAKSI EKSTRAK ETANOL DAUN AFRIKA (Vernonia amygdalina Delile)PADA TIKUS DIABETES NEFROPATI. Tesis thesis, Fakultas Farmasi.

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Abstract

Diabetes mellitus (DM) type 2 can cause complications such as diabetic nephropathy (DN). An increase in serum creatinin and BUN as well as decreased serum albumin into the parameters of the presence of damage to the kidneys. Africa leaves (Vernonia amygdalina Delile) can be used as a treatment on the conditions of this study.This research purpose is to know antihyperglikemi activity fractionsfraction ethanol extracts of Africa leaves, repair and regeneration kidney function. This research used 35 white male wistarrats conditioned DM type 2 for 24 days. Rats were divided into 7 groups, group I, group II negative control using STZNA 65 mg/kg and 230 mg/kg, group III positive control with glibenklamid 0.45 mg/kg, Group IV ethanol extracts of africa leaves 400 mg/kg, Group V fraction nheksan 100 mg/kg BB, Group VI fraction of ethyl acetate 100 mg/kg, and Group VII water fraction 100 mg/kg. Data analysis using ANOVA test followed LSD Post Hoc. The results showed that administering fraction-fraction of ethanolic extract of africa leaves at doses 100 mg/kg BB can lower glucose levels on rat withdiabeticnephropathy. Administering fraction-fraction of ethanolic extracts of africa leaves at dose100 mg/kg rat can improve kidney function and effect on kidney regeneration rat with diabetic nephropathy. Keywords: fractions-fraction ethanolic extracts of africa leaves, creatininserum, diabetic nephropathy, BUN, albumin serum, and renal histopathology.

Item Type:	Thesis (Tesis)
Uncontrolled Keywords:	fractions-fraction ethanolic extracts of africa leaves, creatininserum, diabetic nephropathy, BUN, albumin serum, and renal histopathology
Subjects:	R Medicine > R Medicine (General)
Divisions:	Fakultas Farmasi > Prodi S2 Farmasi
Depositing User:	Mrs NOVI HANDAYANI
Date Deposited:	01 Nov 2019 07:33
Last Modified:	01 Nov 2019 07:33
URI:	http://repo.setiabudi.ac.id/id/eprint/3427

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