AKTIVITAS ANTIDIABETES FRAKSI-FRAKSI EKSTRAK DAUN YACON (Smallanthus sonchifolius) DAN EKSPRESI PROTEIN GLUT 4 JARINGAN OTOT soleus PADA TIKUS RESISTEN INSULIN

umiwa, Novita Natalia Gabriela T (2019) AKTIVITAS ANTIDIABETES FRAKSI-FRAKSI EKSTRAK DAUN YACON (Smallanthus sonchifolius) DAN EKSPRESI PROTEIN GLUT 4 JARINGAN OTOT soleus PADA TIKUS RESISTEN INSULIN. Tesis thesis, Universitas Setia Budi Surakarta.

	Text BAB I.pdf Download (612kB)
	Text BAB II.pdf Restricted to Registered users only Download (627kB) | Request a copy
	Text BAB III.pdf Restricted to Registered users only Download (232kB) | Request a copy
	Text BAB V.pdf Restricted to Registered users only Download (31kB) | Request a copy
	Text BAB VI - Lampiran.pdf Restricted to Registered users only Download (2MB) | Request a copy
	Text Form Pernyataan Publikasi.pdf Download (720kB)
	Text INTISARI-ABSTRACT.pdf Download (16kB)
	Text BAB IV.pdf Restricted to Registered users only Download (459kB) | Request a copy

Abstract

Yacon is an Andes, PERU crop which known to have antidiabetic activity. This plant consist phenolic compounds and its derivates have antidiabetic activity. The aim of this study was to determine antidiabetic activity of extracts and fractions of yacon leaves to provide antidiabetic activity which decreasing blood glucose levels and increase insulin receptor sensitivity through GLUT-4 expression in soleus muscle in treating insulin resistance. Thirty-five male Wistar rats were randomly divided into seven groups include normal control, Na-CMC, positive control, ethanol extract, water fraction of yacon leaf, n-heksane fraction and ethyl acetate fraction. We fed male Wistar rats a high fat diet with the composition of pellet (80%), lard (15%, and quail egg yolk (5%). All rats (except normal control) were given a high fat and fructose diet treatment everyday for 45 days. Fructose is given 180mg/100g BB once per day orally. Insulin sensitivity was evaluated by insulin tolerance test. Translocation pf GLUT-4 in rat muscle using immunohistochemical. The result showed that fractions and ethanol extract of yacon leaves increase blood glucose level within 21 days in rats and 10 mg/ Kg BB ethyl acetate had given the highest percentage of hypoglycemic after normal control also increase GLUT-4 protein translocation in soleus muscle by 83,22% in Diabetes type II insulin resistance. Keywords : Smallanthus sonchifolius, high fat diet, GLUT-4

Item Type:	Thesis (Tesis)
Uncontrolled Keywords:	Smallanthus sonchifolius, high fat diet, GLUT-4
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Fakultas Farmasi > Prodi S2 Farmasi
Depositing User:	Mrs NOVI HANDAYANI
Date Deposited:	01 Nov 2019 07:29
Last Modified:	01 Nov 2019 07:29
URI:	http://repo.setiabudi.ac.id/id/eprint/3450

Actions (login required)

View Item