PENGARUH KONSENTRASI HPMC PADA SEDIAAN EMULGEL EKSTRAK ETANOL DAUN BANDOTAN (Ageratum conyzoiddes L.)TERHADAP SIFAT FISIK DAN PENYEMBUHAN INFEKSI Staphylococcus aureus ATCC 25923 PADA KELINCI

Nugrahani, Agustina Sri (2019) PENGARUH KONSENTRASI HPMC PADA SEDIAAN EMULGEL EKSTRAK ETANOL DAUN BANDOTAN (Ageratum conyzoiddes L.)TERHADAP SIFAT FISIK DAN PENYEMBUHAN INFEKSI Staphylococcus aureus ATCC 25923 PADA KELINCI. Skripsi thesis, Universitas Setia Budi.

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Abstract

Bandotan leaves (Ageratum conyzoiddes L.) are used as an alternative to cure infections. Emulgel can increase effectiveness, comfort in topical use. Good emulgel physical properties depend on the use of gelling agent, one of which is HPMC. The purpose of this study was to determine the effect of variations of HPMC gelling agent on the physical properties and healing activities of the infection of bandotan leaf extract emulgel. Emulgel was formulated into three formulas with variations of HPMC FI 2%, FII 3% and FIII 4% using extracts of 20% for each formula. Tests of emulgel physical properties include organoleptic test, pH, homogeneity, viscosity, adhesion, dispersion, and freeze and thaw test. Infection healing activity was tested in rabbits infected subcutaneously by Staphylococcus aureus ATCC 25923 and then observed for reduced wound diameter. The results were analyzed using two way ANOVA. The results showed an increase in HPMC levels caused increasingly thick, consistency, increased viscosity and adhesion, decreased dispersion and pH, but did not affect homogeneity. Test for infection healing showed an increase in HPMC ability to release different active substances showed the length of infection wound healing of FI 16 days (99.6%), FII 12 days (99.82%) and FIII 14 days (99.72%).The emulgel consentration of gelling agent HPMC 3% (FII) showed the best effect in healing infection and its physical characteristics fulfilled the percentage of infection healing almost equivalent to positive control 8 days (99,45%). Keywords: Bandotan leaves (Ageratum conyzoiddes L.), Emulgel, Infection wounds, HPMC, Rabbits

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	Bandotan leaves (Ageratum conyzoiddes L.), Emulgel, Infection wounds, HPMC, Rabbits
Subjects:	R Medicine > R Medicine (General)
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Tifany Nur Arfiana
Date Deposited:	01 Nov 2019 03:40
Last Modified:	01 Nov 2019 03:40
URI:	http://repo.setiabudi.ac.id/id/eprint/3474

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