BUDI, Dewi Sinta Setyaning (0201) PENGARUH EKSTRAK ETANOL DAUN PETAI (Parkia speciosa Hassk.) TERHADAP PENURUNAN KADAR GLUKOSA DARAH DAN AKTIVITAS ENZIM GLUTATION PEROKSIDASE PADA TIKUS DIABETES. Skripsi thesis, Universitas Setia Budi Surakarta.
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Abstract
Petai leaf (Parkia speciosa) is the plant that have an antidiabetic and antioxidant strong effects. This study aims to determine the effects of antidiabetic and increased activity of glutathione peroxidase enzyme from petai leaf extract in alloxan-induced DM rats. This study was used 6 groups of male wistar rats. Control I (normal group); Group II (negative control); group III (positive control) and group IV-VI consecutively (petai leaf extract dose 50 mg / kg bw; 100 mg / kg bw; 200 mg / kg bw) All induced alloxan with doses of 30mg / 200g bw rat except in control. After 14 days of treatment, blood glucose levels were measured using GOD-PAP method and glutathione peroxidase enzyme activity was measured in mouse liver tissue The data were analyzed by one way anova method (p <0.05) followed by Tukey test. The results of study should that petai leaf extract has the activity to decrease blood glucose levels and increased glutathione peroxidase enzyme levels. The most effective dose of petai leaf extract is on the dose of 200 mg / kg BW which there is an decreased of blood glucose levels, with last blood glucode levels of 119,76 mg/dl and increased glutathione peroxidase enzyme level of 71,61 U / mg, it has not significant difference with positive control. Keywords : petai leaf, decrease blood glucose levels, glutathione peroxidase, antioxidant.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | petai leaf, decrease blood glucose levels, glutathione peroxidase, antioxidant. |
| Subjects: | Q Science > QK Botany |
| Divisions: | Fakultas Farmasi > Prodi S1 Farmasi |
| Depositing User: | Tifany Nur Arfiana |
| Date Deposited: | 22 Feb 2019 09:41 |
| Last Modified: | 22 Feb 2019 09:41 |
| URI: | http://repo.setiabudi.ac.id/id/eprint/348 |
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