FORMULASI FAST DISINTEGRATING TABLET NATRIUM DIKLOFENAK DALAM KOMPLEKS INKLUSI β-SIKLODEKSTRIN MENGGUNAKAN CROSCARMELLOSE SODIUM DAN SODIUM STARCH GLYCOLATE SEBAGAI SUPERDISINTEGRANT

DAMAYANTI, Diah Wuri (2018) FORMULASI FAST DISINTEGRATING TABLET NATRIUM DIKLOFENAK DALAM KOMPLEKS INKLUSI β-SIKLODEKSTRIN MENGGUNAKAN CROSCARMELLOSE SODIUM DAN SODIUM STARCH GLYCOLATE SEBAGAI SUPERDISINTEGRANT. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Natrium diclofenac is a kind of NSAID (Non-Steroidal Anti-Inflammatory Drug), BCS class II and has a bitter taste that reduces the comfort of the patients who are getting difficulties in swallowing a pill. The alternative FDT (Fast Disintegrating Tablet) of natrium diclofenac in the β-cyclodextrin inclusion complex is a way to solve the problem. This research aims to determine the effect of superdisintegrant combination between croscarmellose sodium and sodium starch glycolate on FDT natrium diclofenac on physical quality and dissolution profile. The inclusion complex was made by kneading method with a ratio 1 : 1,5 molar, then characterized by Fourier-Transform Infrared (FTIR) and Differential Scanning Calorymetry (DSC). FDT was made by direct compression method with the variation of crosscarmellose sodium and sodium starch glycolate concentration with the ratio of 0:100%; 25:75%;50:50%;75:25%;100:0%. The testing of the uniformity of weight, content, hardness, friability, wetting time, disintegration time (in vivo & in vitro), and dissolution was done to determine the physical quality of FDT natrium diclofenac. The result shows that the combination of superdisintegrant croscarmellose sodium and sodium starch glycolate can reduce hardness, friability, wetting time, disintegration time (in vivo & in vitro). The combination of superdisintegrant croscarmellose sodium and sodium starch glycolate (25:75%) has an effect on the physical quality and the best drug release of FDT natrium diclofenac. Key words: fast disintegrating tablet (FDT), β-Cyclodextrin Inclusion Complex, natrium diclofenac, croscarmellose sodium, sodium starch glycolate

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	fast disintegrating tablet (FDT), β-Cyclodextrin Inclusion Complex, natrium diclofenac, croscarmellose sodium, sodium starch glycolate
Subjects:	R Medicine > R Medicine (General)
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Tifany Nur Arfiana
Date Deposited:	22 Feb 2019 09:41
Last Modified:	22 Feb 2019 09:41
URI:	http://repo.setiabudi.ac.id/id/eprint/351

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