UJI DISOLUSI TERBANDING DAN PENETAPAN KADAR SERTA MUTU FISIK TABLET GLIMEPIRID GENERIK DENGAN INOVATOR

Sanan, Antonius Oenunu (2019) UJI DISOLUSI TERBANDING DAN PENETAPAN KADAR SERTA MUTU FISIK TABLET GLIMEPIRID GENERIK DENGAN INOVATOR. Skripsi thesis, Universitas Setia Budi.

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Abstract

Generic drug is one of the alternative options for the community beside trade names drugs and innovator drugs. Social opinions about the low quality of generic drugs are because the prices are relatively cheaper than the branded drugs or innovators drugs. The purpose of this research is to know the similarity dissolution profile and physical quality glimepiride generic tablets with innovator drugs. The test was done by dissolution comparative test. Dissolution comparative test using glimepiride tablet consists of 1 product of innovator, 2 products of generic trademarked and 2 products of generic logo. The test was done using dissolution tool type 2 (paddle method), with the medium of 900 mL aqueous phosphate buffer in pH 7,8 with temperature 37° C by stirring fifty round per minute speed. The results of this research is there are similarities dissolution profile found between generic trademarked products and innovator products indicated by the value of F2 among the 50-100, while 1 of 2 generic logo products have different dissolution profile with innovators products. The cumulative amount of the fifth brands tablets of glimepiride dissolved in aqueous phosphate buffer in pH 7.8 until 60 minutes is more than 80%, so the amount of the dissolved drugs meet the requirements of third edition of Indonesian Pharmacopoeia . Keywords : glimepirid, comparative dissolution test, innovator product, generic product

Item Type: Thesis (Skripsi)
Uncontrolled Keywords: glimepirid, comparative dissolution test, innovator product, generic product
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Prodi S1 Farmasi
Depositing User: Tifany Nur Arfiana
Date Deposited: 01 Nov 2019 03:44
Last Modified: 01 Nov 2019 03:44
URI: http://repo.setiabudi.ac.id/id/eprint/3528

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