FORMULASI DAN UJI DAYA HAMBAT OBAT KUMUR EKSTRAK KAYU SIWAK (Salvadora persica Linn.) TERHADAP AKTIVITAS BAKTERI Streptococcus mutans ATCC 25175 SECARA in vitro

Rahmawati, Fadhilah Rizka (2019) FORMULASI DAN UJI DAYA HAMBAT OBAT KUMUR EKSTRAK KAYU SIWAK (Salvadora persica Linn.) TERHADAP AKTIVITAS BAKTERI Streptococcus mutans ATCC 25175 SECARA in vitro. Skripsi thesis, Universitas Setia Budi.

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Abstract

Dental caries caused by the bacteria Streptococcus mutans was a disease that has a very high prevalence in Indonesia. Mouthwash can clean parts of the teeth that are difficult to clean with toothpaste. Siwak wood (Salvadora persica Linn.) has antibacterial activity. The purpose of this study was to formulate mouthwash from siwak wood extract which has antibacterial against the Streptococcus mutans bacteria. The extract was obtained by maceration using 70% ethanol solvent. Making mouthwash with extract concentration of 1%, 3%, 5%, and 7%. Physical quality testing and stability using organoleptic test, pH, and viscosity. The result of the data were tested statistically by Paired Samples T-Test. Antibacterial activity testing using the cakram diffusion method. The result of the data in the form of the diameter of the inhibition zone were tested statistically by One Way Anova SPSS method, Tukey HSD. The result showed that the formulation of siwak wood mouthwash extract had good physical quality and stability for up to 21 days. Siwak wood extract mouthwash has the potential as an antibacterial. Mouthwash formulation with extract concentration of 1%, 3%, 5%, and 7%, respectively resulted in inhibition zones of 11,93 mm ± 0,81, 16,53 mm ± 0,68, 17,26 mm ± 0,45, and 23, 96 mm ± 0,94. Mouthwash formulation of 3% has the most effective activity. Keywords : Mouthwash, Salvadora persica Linn., Streptococcus mutans, Diffusion.

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	Mouthwash, Salvadora persica Linn., Streptococcus mutans, Diffusion.
Subjects:	R Medicine > RV Botanic, Thomsonian, and eclectic medicine
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Tifany Nur Arfiana
Date Deposited:	01 Nov 2019 03:39
Last Modified:	01 Nov 2019 03:39
URI:	http://repo.setiabudi.ac.id/id/eprint/3648

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