UJI AKTIVITAS TONIKUM EKSTRAK DAN FRAKSI BUAH PARE (Momordica charantia L.) TERHADAP MENCIT PUTIH JANTAN

Cahyani, Laily Julita Dwi (2019) UJI AKTIVITAS TONIKUM EKSTRAK DAN FRAKSI BUAH PARE (Momordica charantia L.) TERHADAP MENCIT PUTIH JANTAN. Skripsi thesis, Universitas Setia Budi.

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Abstract

Bitter melon fruit (Momordica charantia Linn.) Is a plant that has properties as a tonic. Bitter melon contains flavonoids, saponins, tannins, and steroids / triterpenoids. The purposes of this study was to determine the extract tonicum activity and fraction of bitter melon fruit on male white mice and determine the difference in tonic effect on each fraction and to know which fraction was the most equivalent to positive control of caffeine. Extraction was done by maceration method using 70% ethanol, then fractionated using n-hexane, ethyl acetate, and water solvents. The results of extraction and fractionation were carried out by tonic activity test using Natatory Exhaustion method. This research was divided into 6 groups, each group using 5 male white mice. Group I negative control aquadest, II positive control (caffeine) 100 mg / Kg BB mice, III ethanol extract 4 mg / 20 gBB mice, IV water fraction 3.12 mg / 20 g BB mice, V ethyl acetate fraction 0.76 mg / 20 g BB mice, VI nhexane fraction 0.24 mg / 20 g BB mice. The results showed that ethanol extract and fraction of bitter melon fruit had tonic activity, ethyl acetate fraction was the highest fraction of the fatigue time difference compared to other fractions but was not equivalent to the positive control of caffeine. The test results of ethyl acetate fraction showed tonic activity with percent fatigue time which was 111.62%. Keywords : Bitter melon extract (Momordica charantia Linn.), fraction, Male white mice, Tonicum.

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	Bitter melon extract (Momordica charantia Linn.), fraction, Male white mice, Tonicum.
Subjects:	R Medicine > RV Botanic, Thomsonian, and eclectic medicine
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Tifany Nur Arfiana
Date Deposited:	05 Nov 2019 04:18
Last Modified:	05 Nov 2019 04:18
URI:	http://repo.setiabudi.ac.id/id/eprint/3717

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