Paristi, Laras Mega (2019) PENGARUH MUATAN GELLING AGENT DAN ENHANCER TERHADAP PROFIL DIFUSI DAN AKTIVITAS ANTIOKSIDAN NANOEMULGEL RESVERATROL. Skripsi thesis, Universitas Setia Budi.
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Abstract
Resveratrol (3, 5, 4 '-trihydroxystilbene) is a polyphenol compound that has antioxidant activity but is insoluble in water (0.05 mg/mL), so that it is made of nanoemulgel preparations that can increase the solubility of resveratrol. The study aims to obtain a nanoemulsion formula to be incorporated into the gelling agent (Nanoemulgel), knowing the effects of payload gelling agent and enhancers against diffusion profiles and the antioxidant activity of resveratrol Nanoemulgel. The Formula of Nanoemulsion is based on oil screening, surfactant, and Cosurfactant and is made by self-emulsification method. The Nanoemulsion Formula is selected based on the Transmittan percent value, drug loading, particle size and zeta potential. The selected Formula will be accredited with gelling agent Chitosan or Carbopol and addition of Transcutol CG enhancers so that the Nanoemulgel is formed. Nanoemulgel characterizes viscosity, diffusion profile, freeze thaw and analysed its antioxidant activities. Data obtained further processed with the Design Expert version 7.1.5 to know the effect of payload gelling agent and enhancers. The results of screening nanoemulsion components obtained Capryol as oil, Kollipor EL as surfactant, and PEG 400 as a cosurfactant with oil ratio: surfactant 4:6 and surfactant: cosurfactant 2:1 concentration 2%. The Formula of Nanoemulsion produces, a percent value of transmittan 76-89,8%, drug loading 105, 42 mg/mL, particle size 38.48 ± 0, 35nm, and Zeta potential-8.3675 mV. The viscosity of the Carbopol Nanoemulgel decreased after the 6-cycle freeze thaw test. The content of positive gelling agents (Chitosan) has a dominant effect on the cumulative response, flux, and total AUC of the enhancers. Interactions between gelling agent and enhancer can increase the antioxidant inhibition change response. Keywords: Resveratrol, nanoemulgel, charged gelling agent, diffusion, antioxidant activity.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | Resveratrol, nanoemulgel, charged gelling agent, diffusion, antioxidant activity. |
| Subjects: | R Medicine > R Medicine (General) |
| Divisions: | Fakultas Farmasi > Prodi S1 Farmasi |
| Depositing User: | Tifany Nur Arfiana |
| Date Deposited: | 05 Nov 2019 04:18 |
| Last Modified: | 05 Nov 2019 04:18 |
| URI: | http://repo.setiabudi.ac.id/id/eprint/3718 |
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