OPTIMASI KOMPONEN EFFERVESCENT DAN PEG 6000 TERHADAP KARAKTERISASI DAN UJI MUTU FISIK TABLET EFFERVESCENT MELOKSIKAM

Astari, Meilany Berti (2019) OPTIMASI KOMPONEN EFFERVESCENT DAN PEG 6000 TERHADAP KARAKTERISASI DAN UJI MUTU FISIK TABLET EFFERVESCENT MELOKSIKAM. Skripsi thesis, Universitas Setia Budi.

	Text INTISARI.pdf Download (91kB)
	Text PERNYATAAN PUBLIKASI.pdf Download (379kB)
	Text COVER-BAB I.pdf Download (487kB)
	Text BAB II.pdf Download (428kB)
	Text BAB III.pdf Download (213kB)
	Text BAB IV.pdf Download (757kB)
	Text BAB V-LAMPIRAN.pdf Download (3MB)

Abstract

Meloxicam is one of the NSAID (Non-steroidal Anti-inflammatory) drugs an oxycam group that are widely used for the treatment of rheumatoid arthritis and other joint diseases. Meloxicam belongs in Class 2 BCS which has high permeability and low solubility. The limitations of this compound can be solved by making the preparation of effervescent tablets dispersed with PEG 6000 with a ratio of 1: 4 and 1: 6. The purpose of this research is to optimize the combination of effervescent components of citric acid and PEG 6000 against the characterization and physical quality of of effervescent meloxicam tablets. The method of produced solid dispersion disperses the dispersed PEG 6000 using the melting method, while the method of making effervescent tablets is oxidizing using a direct-press method. The optimization process was carried out using the factorial design optimization method, with the component effervescent citric acid and PEG 6000 factor. The results of the granule physical quality test will be analyzed using Software Design-Expert version 7.1.6 trial version based on Q3 critical point, DE15, increased solubility, and increased humidity. Based on the results of superimposed contour plot optimization the optimum formula of effervescent meloxicam tablet was obtained with a combination of 25% citric acid effervescent component and the concentration of PEG 6000 of 6x of citric acid, with value desirability of 0.947. The results showed that the optimum combination of citric acid effervescent components and PEG 6000 resulted in Q3 17,97%, DE15 46,89%, increased the solubility of 152% or 1,52 times from pure meloxicam, and increased moisture by 9,3%. Key words : Meloxicam, effervescent tablets, solid dispersion, citric acid, PEG 6000, and factorial design.

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	Meloxicam, effervescent tablets, solid dispersion, citric acid, PEG 6000, and factorial design.
Subjects:	R Medicine > R Medicine (General)
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Tifany Nur Arfiana
Date Deposited:	07 Nov 2019 06:57
Last Modified:	07 Nov 2019 06:57
URI:	http://repo.setiabudi.ac.id/id/eprint/3748

Actions (login required)

View Item