UJI AKTIVITAS ANTIKONVULSAN EKSTRAK ETANOL DAUN PUTRI MALU (Mimosa pudica L.) TERHADAP MENCIT PUTIH JANTAN YANG DI INDUKSI INH

Syaifi, Muhammad Akib (2019) UJI AKTIVITAS ANTIKONVULSAN EKSTRAK ETANOL DAUN PUTRI MALU (Mimosa pudica L.) TERHADAP MENCIT PUTIH JANTAN YANG DI INDUKSI INH. Skripsi thesis, Universitas Setia Budi.

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Abstract

Epilepsy is a neurological disease characterized by episodes of seizures and can be accompanied by loss of awareness of the patient. Putri malu leaves (Mimosa pudica L.) contain flavonoid compounds, alkaloids, tannins, saponins which have been thought to have anticonvulsant activity. The purpose of this study was to determine the activity of ethanol extract of putri malu leaves as anticonvulsion and to determine the effective dose of ethanol extract of putri malu in reducing seizures in INH-induced mice. The extract of leaf putri malu is obtained from the maceration process. This research do with all the male mice divided into as many as 25 tail 5. Group the group 1 ( negative control ) given solution CMC Na, of group II, III, and IV each given extract ethanol leaves putri malu (Mimosa pudica L.) by 100/kgBB, dose of mg 200 mg/kgBB, and 400 mg/kgbb, the group V ( positive control ) given phenobarbital 100 mg/kgBB. All groups were given treatment in accordance with his group for 7 day peroral, in except phenobarbital granted only on the 7 day, six days before given a solution of CMC Na. On the 7 day , after 1 hours the provision of all mice from each group induced isoniazid in intraperitonial.The data that observed in form of tonic spasms public clonic spasm which includes, onset the duration of, the frequency, and the death toll mice. Data analyzed by the level of faith 95 %. The research result showed that 400mg/kgBB dose can extend onset, accelerate, duration reduce the frequency of seizures and the death toll. Of the result showed that extracts ethanol leaves of putri malu (Mimosa pudica L.) 400/kgBB mg dose potentially a anticonvulsant. Keyword : epilepsy, Mimosa pudica , Anticonvulsant, Isoniazid

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	epilepsy, Mimosa pudica , Anticonvulsant, Isoniazid
Subjects:	R Medicine > RV Botanic, Thomsonian, and eclectic medicine
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Tifany Nur Arfiana
Date Deposited:	07 Nov 2019 06:59
Last Modified:	07 Nov 2019 06:59
URI:	http://repo.setiabudi.ac.id/id/eprint/3750

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