FORMULASI DAN EVALUASI FISIK SEDIAAN FAST DISINTEGRATING TABLET AMLODIPIN BESILAT MENGGUNAKAN KOMBINASI CROSPOVIDONE DAN CROSCARMELLOSE SODIUM SEBAGAI SUPERDISINTEGRANT

Ikhsan, Muksalmina (2019) FORMULASI DAN EVALUASI FISIK SEDIAAN FAST DISINTEGRATING TABLET AMLODIPIN BESILAT MENGGUNAKAN KOMBINASI CROSPOVIDONE DAN CROSCARMELLOSE SODIUM SEBAGAI SUPERDISINTEGRANT. Skripsi thesis, Universitas Setia Budi.

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Abstract

Amlodipine besylate is Biopharmaceutical Classsification System (BCS) class I. Bitter taste and uncomfortable feel when consumed by geriatric patients is weakness of conventional tablet amlodipine besylate, so it is formulated into Fast Disintegrating Tablet (FDT). FDT amlodipine besylate uses combination of superdisintegrant of crosspovidone and croscarmellose sodium to make tablets crush in mouth. Purpose of this study was to determine effect of combination of crospovidone and croscarmellose sodium on physical properties and to determine the best concentration of combinations crospovidone and croscarmellose sodium on the physical properties of FDT amlodipine besylate. FDT amlodipine besylate was made by direct compression by determining five formulas concentrations of combination of crospovidone and croscarmellose sodium namely formula 1 (100%: 0%), formula 2 (75%: 25%), formula 3 (50%: 50%), formula 4 (25%: 75%), formula 5 (0%: 100%). FDT amlodipine besylate then tested its physical quality namely, uniformity of content, hardness, friability, wetting time, disintegration time, taste responsiveness. Resultss of physical quality were analyzed using SPSS software version 23. Combination of crospovidone and croscarmellose sodium results the best hardness of 4.60 kg with 0.11% friability in formula 2, and does not make a significant difference in each formula on uniformity of content and taste responsiveness. Formula 3 with the combination concentration of crospovidone and croscarmellose sodium (50%:50%) is the best formula with the fastest wetting time of 9 seconds, the fastest in vitro disintegration time of 21 seconds and the fastest in vivo disintegration of 23 seconds. Keyword: FDT, amlodipine besylate, crospovidone, croscarmellose sodium

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	FDT, amlodipine besylate, crospovidone, croscarmellose sodium
Subjects:	R Medicine > R Medicine (General)
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Tifany Nur Arfiana
Date Deposited:	16 Nov 2019 02:26
Last Modified:	16 Nov 2019 02:26
URI:	http://repo.setiabudi.ac.id/id/eprint/3766

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