UJI AKTIVITAS SITOTOKSIK EKSTRAK ETANOL DAUN BINAHONG (Anredera cordifolia (Ten.) Steenis) TERHADAP KULTUR SEL KANKER HATI HepG2

Nashihah, Qori’atun (2019) UJI AKTIVITAS SITOTOKSIK EKSTRAK ETANOL DAUN BINAHONG (Anredera cordifolia (Ten.) Steenis) TERHADAP KULTUR SEL KANKER HATI HepG2. Skripsi thesis, Universitas Setia Budi.

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Abstract

Cancer is one of the diseases that cause many deaths in the world. One type of cancer which increasing number every year is liver cancer. Binahong (Anredera cordifolia (Ten.) Steenis) is the most studied plant because it is able to cure various diseases traditionally and scientifically demonstrates its potential as an anti-cancer agent. This study aims to determine cytotoxic activity by measuring the IC50 score and selectivity index of ethanol extract in binahong leaves towards HepG2 liver cancer cell cultures. The research is conducted through several process, such as extracting binahong leaves using maceration method with 70% ethanol. Whereas cytotoxic test ethanol extract of binahong leaves is conducted by using MTT (Microculture Tetrazolium Technique) method which use a series of concentrations (1000; 500; 250; 125; 62.5; 31.2; 15.6) µg/mL and IC50 score are calculated through linear regression. Selectivity index is done to determine cytotoxic selectivity obtained by comparing IC50 score of vero cells to IC50 score of HepG2 liver cancer cell cultures. Cytotoxic test results of binahong leaves ethanol extract shows moderate activity towards HepG2 liver cancer cell culture with IC50 score of 276,968 µg/mL, but has high cytotoxic selectivity with selectivity index score 5,741. Keywords: Binahong leaves, cytotoxic, HepG2 cell

Item Type: Thesis (Skripsi)
Uncontrolled Keywords: Binahong leaves, cytotoxic, HepG2 cell
Subjects: Q Science > QK Botany
Divisions: Fakultas Farmasi > Prodi S1 Farmasi
Depositing User: Tifany Nur Arfiana
Date Deposited: 15 Nov 2019 07:00
Last Modified: 15 Nov 2019 07:00
URI: http://repo.setiabudi.ac.id/id/eprint/3825

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