OPTIMASI DAN KARAKTERISASI KOMPONEN STEARIN DAN PEG 1000 PADA FORMULASI SOLID SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEM (S-SNEDDS) NARINGENIN DENGAN 22 FACTORIAL DESIGN

Purbasari, Rachel Pingkan (2019) OPTIMASI DAN KARAKTERISASI KOMPONEN STEARIN DAN PEG 1000 PADA FORMULASI SOLID SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEM (S-SNEDDS) NARINGENIN DENGAN 22 FACTORIAL DESIGN. Skripsi thesis, Universitas Setia Budi.

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Abstract

Naringenin is a natural flavanone which belongs to the flavonoid group which is known to has various biological activities such as antidiabetic, antidepressants, immunomodulators, antitumor, anti-inflammatory, and antioxidants. Naringenin is almost insoluble in water and dissolves in organic solvents such as alcohol. Bioflavonoids are difficult to absorb on oral consumption, only 15% of naringenin will be digested and absorbed in the human digestive tract. The preparation of naringenin solid SNEDDS has stearin, kolliphor EL, and PEG 1000 components so that it can increase bioavailability. The optimum formula for base SNEDDS naringenin was obtained by the 22 factorial design method using the Design Expert 7.1.5 program with characteristics such as emulsification time and% transmittance. The optimum formula was used to determine the level of naringenin that can be dissolved in the basis of SNEDDS naringenin solid which is 20mg per gram basis. The optimum formula for selected SNEDDS naringenin is a formula with a comparison 1 part of stearin and PEG 1000 3 parts with a characterization of 25.33 seconds emulsification, % transmittance of 33.13%, dissolution AUC of 2432.51, dissolution Q30 of 102, 93%, and the diffusion constant is 0.169. The effect of stearin component on solid SNEDDS naringenin parameters can increase the% transmittance of the solid SNEDDS naringenin formula, while the influence of PEG 1000 components can reduce emulsification time, total AUC and Q30 dissolution test and can reduce the diffusion constant of the solid SNEDDS naringenine formulation. Keywords: naringenin, stearin, PEG 1000, solid SNEDDS, factorial design,

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	naringenin, stearin, PEG 1000, solid SNEDDS, factorial design,
Subjects:	Q Science > QD Chemistry
Depositing User:	Tifany Nur Arfiana
Date Deposited:	15 Nov 2019 07:00
Last Modified:	15 Nov 2019 07:00
URI:	http://repo.setiabudi.ac.id/id/eprint/3826

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