Dewi, Retna Rosiana (2019) MODIFIKASI BENTUK KRISTAL GEMFIBROZIL MELALUI TEKNIK SPHERICAL CRYSTALIZATION MENGGUNAKAN METODE SPHERICAL AGGLOMERATION (SA). Skripsi thesis, Universitas Setia Budi.
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Abstract
Gemfibrozil is the first generation fibric acid group of fibrate derivatives and clofibrates. According to be Biopharmaceous Clasification System (BCS), gemfibrozil include class II drugs which had low solubility and high permeability. Gemfibrozil low solubility in water (practically insoluble) causes low dissolution. This study aimed to obtain spherical crystals and to see the comparison of pure gemfibrozyl and gemfibrozil spherical solubility using the spherical agglomeration method. The process of making this method the parameters used are the number and method of adding liquid brigging, temperature and stirring speed to get the maximum spherical crystal. This study uses 3 formulas with a variation of 2% PVP polymer, 2% PVA, 2% PEG 4000. The manufacturing process uses the Spherical agglomeration method using ethanol (good solvent), water (haze solvent), ethyl acetate (brigging) and polymer addition. Spherical crystals were characterized using optical microscopy, X-ray Difractometry (XRD), Scanning Electron Microscopy (SEM), Gemfibrozil spherical solubility test carried out in aquadest medium and measured by UV-Vis spectrophotometry at a wavelength of 274 nm. The results showed a 1 mm round spherical crystal with a magnification of 50x, on XRD diaphragm showed a sharp peak in the XRD diffractogram of spherical gemfibrozil with a height 10 times lower than pure gemfibrozil showed that crystal modification had occurred without polymorphic changes. Solubility of gemfibrozil spherical 7,307 mg / ml and the yield produced 93,117%. Conclusion, Gemfibrozil has been successfully developed into spherical crystals of the Spherical agglomeration method and can improve solubility and micromeritic properties. Keywords: Gemfibrozil, Spherical Agglomeration Technique, solubility
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | Gemfibrozil, Spherical Agglomeration Technique, solubility |
| Subjects: | Q Science > QD Chemistry |
| Divisions: | Fakultas Farmasi > Prodi S1 Farmasi |
| Depositing User: | Tifany Nur Arfiana |
| Date Deposited: | 14 Nov 2019 07:07 |
| Last Modified: | 14 Nov 2019 07:07 |
| URI: | http://repo.setiabudi.ac.id/id/eprint/3840 |
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