OPTIMASI KOMPONEN EFFERVESCENT DAN PEG 4000 TERHADAP KARAKTERISASI DAN UJI MUTU FISIK TABLET EFFERVESCENT MELOKSIKAM

Agustina, Widia Eka (2019) OPTIMASI KOMPONEN EFFERVESCENT DAN PEG 4000 TERHADAP KARAKTERISASI DAN UJI MUTU FISIK TABLET EFFERVESCENT MELOKSIKAM. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Meloxicam is part into class II Biopharmaceutic Classification System (BCS) which has low solubility with high permeability. Biovailability meloxsicam about 89% high lipofitas with absorption and disolution are limited. Solid dispersion methode can increased the solubility of meloxicam using PEG 4000. The purpose of the research is determine the optimum concentration and characterization of tablets obtained by effervescent components, PEG 4000 and meloxicam based on the factorial design program. This research used 4 formulas obtained from the factorial design optimization program with variations in citric acid concentration of 15% and 25% and PEG 4000 4 and 6 parts of citric acid. Determination of the optimum formula for effervescent meloxicam tablets dispersed by PEG 4000 was obtained from the critical point of efficiency dissolution parameters (DE15), drug dissolved at minute 3 (Q3), increased solubility and increased humidity which was optimized by the factorial design method on the combination of citric acid and PEG 4000 uses an expert software version 8.0.6 trial. The optimum results were obtained for the optimum formula with a combination of 15% citric acid and 4 parts PEG 4000. The optimization results are obtained based on critical parameters that provide the most dominant influence on the preparation with a value of DE15 of 43,01%, Q3 22,38 %, an increase in humidity of 34.29% and an increase in solubility of 134,96%. Dissolution results showed that Q3 and DE15 of the solid dispersion of meloxicam had high value than pure meloxicam and the solubility of solid dispersion of meloxicam increased by 134.96% or 1.34 times that of pure meloxicam. Key Word : Meloxicam, solid dispersion, citric acid, PEG 4000, effervescent tablet, factorial design

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	Meloxicam, solid dispersion, citric acid, PEG 4000, effervescent tablet, factorial design
Subjects:	R Medicine > RM Therapeutics. Pharmacology
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Mrs NOVI HANDAYANI
Date Deposited:	16 Nov 2019 03:12
Last Modified:	16 Nov 2019 03:12
URI:	http://repo.setiabudi.ac.id/id/eprint/3908

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