POLA SENSITIVITAS Klebsiella sp. DARI SPUTUM PASIEN PNEUMONIA DI RSUD Dr. MOEWARDI SURAKARTA TERHADAP ANTIBIOTIK SIPROFLOKSASIN, AZITROMISIN, GENTAMISIN, DAN IMIPENEM

Winata, Moh. Ghazali Suryadi (2019) POLA SENSITIVITAS Klebsiella sp. DARI SPUTUM PASIEN PNEUMONIA DI RSUD Dr. MOEWARDI SURAKARTA TERHADAP ANTIBIOTIK SIPROFLOKSASIN, AZITROMISIN, GENTAMISIN, DAN IMIPENEM. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Pneumonia is an acute lower respiratory tract infection. The most common microorganism that causes pneumonia is Klebsiella pneumonia. The purpose of this study was to isolate the bacteria Klebsiella sp. from sputum pneumonia patients at RSUD Dr. Moewardi and know the sensitivity pattern of antibiotics ciprofloxacin, azithromycin, imipenem, and gentamicin against Klebsiella sp. The obtained sputum sample was isolated on Mac Conkey agar media. The results of isolation were identified in Gram stain, capsule staining, and biochemical tests. Sensitivity test method with disk diffusion. Inhibition zone results formed from antibiotic discs, compared with CLSI 2017 (Clinical and Laboratory Standards Institute) standards. Data analysis uses tabulations and bar charts to see the percentage level of antibiotic sensitivity patterns. This research was conducted on 40 samples of patients with pneumonia in Dr. Moewardi 26 positive samples contained Klebsiella sp. and 14 negative samples of Klebsiella sp. Percentage of ciprofloxacin antibiotic sensitivity pattern 88.89%, intermediate 11.11%, azithromycin sensitive 29.63%., Resistance 70.37%., Sensitive imipenem 74.07%. 18.52%., Sensitive gentamicin 48.15%., Intermediate 51.85%. The highest level of sensitivity is ciprofloxacin effective against Klebsiella sp. by inhibiting the enzymes topoisomerase II (DNA gyrase) and topoisomerase IV required by bacteria in the process of replication, transcription, repair, and recombination of DNA. Keywords: Pneumonia, Klebsiella sp., Identification, sensitivity test, antibiotics

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	Pneumonia, Klebsiella sp., Identification, sensitivity test, antibiotics
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Mrs NOVI HANDAYANI
Date Deposited:	13 Feb 2020 03:36
Last Modified:	13 Feb 2020 03:36
URI:	http://repo.setiabudi.ac.id/id/eprint/4100

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