UJI AKTIVITAS SITOTOKSIK EKSTRAK DAN FRAKSI KULIT BUAH JERUK NIPIS (Citrus aurantifolia Swingle) TERHADAP SEL KANKER PAYUDARA MCF-7

Nisa, Sabila Alfa (2019) UJI AKTIVITAS SITOTOKSIK EKSTRAK DAN FRAKSI KULIT BUAH JERUK NIPIS (Citrus aurantifolia Swingle) TERHADAP SEL KANKER PAYUDARA MCF-7. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Breast cancer is the leading cause of cancer deaths in developing countries in women. Lime peel (C. aurantifolia) contains essential oil and hesperidin which is known to have an inhibitory effect proliferation cancer cells. The aims of this study was to identify cytotoxic activity of extract and fraction lime peel (Citrus aurantifolia Swingle) against breast cancer cells MCF-7. The method used is a method Microtetrazolium (MTT) assay. Principle test MTT is measure cellular activity of enzymes mitokondria reduktase in mitochondria for reducing salt Methylthiazol Tetrazolium (MTT). The variation of concentration used is 1000; 500; 250; 125; 62.5; 31.25; 15.625 μg/ml. The results of this study showed extract and fraction lime peel has cytotoxic activity against breast cancer cells MCF-7 with value IC50 extract 306.53 μg/ml, nheksana fraction 66,97 μg/ml, ethyl acetate fraction 199,91 μg/ml, and water fraction 287.40 μg/ml. Extract and fraction hasn’t cytotoxic activity against vero cell with selectivity index value 1.943 x 103, n-heksana fraction 39,50; ethyl acetate fraction 42.59; and water fraction 75.25. The group compounds who have cytotoxic activity are essential oil and flavonoid compounds. Extract and fraction lime peel has the potential to be developed as a chemopreventive agent. Key Words: Lime peel (C. aurantifolia), Breast cancer, MCF-7 Cells, Sitotoxic, MTT.

Item Type: Thesis (Skripsi)
Uncontrolled Keywords: Lime peel (C. aurantifolia), Breast cancer, MCF-7 Cells, Sitotoxic, MTT.
Subjects: Q Science > QK Botany
Divisions: Fakultas Farmasi > Prodi S1 Farmasi
Depositing User: Mrs NOVI HANDAYANI
Date Deposited: 13 Feb 2020 03:36
Last Modified: 13 Feb 2020 03:36
URI: http://repo.setiabudi.ac.id/id/eprint/4102

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