OPTIMASI FORMULA FAST DISINTEGRATING TABLET (FDT) METOKLOPRAMID HCl DENGAN SUPERDISINTEGRANT CROSPOVIDONE DAN FILLER-BINDER CELLACTOSE® DENGAN METODE SIMPLEX LATTICE DESIGN

Sholikha, Ni’matus (2019) OPTIMASI FORMULA FAST DISINTEGRATING TABLET (FDT) METOKLOPRAMID HCl DENGAN SUPERDISINTEGRANT CROSPOVIDONE DAN FILLER-BINDER CELLACTOSE® DENGAN METODE SIMPLEX LATTICE DESIGN. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Fast Disintegration Tablets or FDT can be changed quickly in tablets saliva without the need for water, the pharmacological effect is faster than conventional tablets. This research was conducted to determine the combination of crospovidone and cellactose® on physical quality and the release of active substances to determine the most optimal formula. The simplex lattice design method used in this study with 2 factors: crospovidone and cellactose® in formula 1; formula 2; formula 3 in sequence 0%: 100%; 50%: 50%; 100%: 0%. The method of making tablets is direct pressing, then testing the physical quality of the mass and physical tablets. Determination of the optimal formula based on counterplots from design experts 11 trial with critical parameters, fragility, disintegration time, Q3, and DE3. The results showed that crospovidone increased hardness, disintegration time in vitro and in vivo, while cellactose® increased the powder flow rate of the powder. The proportion of crospovidone 7% (10.5 mg) as superdisintegrant and cellactose® 53% (79.5 mg) as filler-binder provides optimum physical properties of the tablet and drug release to the critical parameters of the tablet namely hardness, friability, disintegration time, Q3, and DE3. Keywords: FDT metoclopramid HCl, crospovidone, cellactose®, simplex lattice design

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	FDT metoclopramid HCl, crospovidone, cellactose®, simplex lattice design
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Mrs NOVI HANDAYANI
Date Deposited:	13 Feb 2020 03:10
Last Modified:	13 Feb 2020 03:10
URI:	http://repo.setiabudi.ac.id/id/eprint/4103

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