THE EFFECT OF CARBONATED DRINK ADDED ON PARACETAMOL DECOMPOSITION BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY

ISWANDI, ISWANDI and WIDYASTUTI, WIDYASTUTI and SUPRIYADI, SUPRIYADI (2012) THE EFFECT OF CARBONATED DRINK ADDED ON PARACETAMOL DECOMPOSITION BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY. In: 24Th FAPA CONGRESS 2012, 13-16 September 2012, BALI. (Unpublished)

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Abstract

Parasetamol is anacetanilide derivative, a metabolite of phenacetin, used as analgesic and antipyretic, not as anti-inflammatory. Carbonated drink is widely consumed and known as ‘soft drink’ or soda drink and has acid property. This study was aimed to know the effect of volume amount of carbonated drink on paracetamol decomposition. The experiment was done using reversed phase HPLC method, with column: C 18 RP (300 x 3,9 mm), mobile phase: methanol-water (1:1), flow rate: 0,8 ml/minute, detector: UV-VIS spectrophotometer (245 nm). External standard method was done for quantitative analysis, where some standards of 50, 70, 100, 120, 150 and 200 ppm concentrations were injected and analyzed the correlation of peak area and concentration. Limit detection of paracetamol is 13,3521 ppm, and limit of quantitation is 44,5069 ppm. The result of recovery test was 97,90 ± 0,12%(b/v). The result of study indicated that carbonated drink affected paracetamol decomposition. The effect of carbonated drink qualitatively was showed by chromatograms of standard paracetamol and the sample that appeared at the fourth minute, while quantitatively paracetamol decomposition was increased, caused by volume variation of carbonated drink. The average assay of decomposed paracetamol at volume addition of carbonated drink of 50 ml was 7,56 ± 0,5%b/v; 100 ml: 14,24 ± 0,47%b/v; 250 ml: 30,11 ± 0,17%b/v. Keywords: paracetamol, carbonated drink, HPLC , decomposition

Item Type: Conference or Workshop Item (Paper)
Uncontrolled Keywords: paracetamol, carbonated drink, HPLC , decomposition
Subjects: R Medicine > R Medicine (General)
Divisions: Fakultas Farmasi > Prodi S2 Farmasi
Depositing User: Mrs NOVI HANDAYANI
Date Deposited: 12 Nov 2020 06:11
Last Modified: 12 Nov 2020 06:11
URI: http://repo.setiabudi.ac.id/id/eprint/4409

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