FORMULASI FAST DISINTEGRATING TABLET CAPTOPRIL MENGGUNAKAN KOMBINASI SUPERDISINTEGRANT CROSCARMELLOSE SODIUM DAN CROSPOVIDONE

YULIANA, Evyta Dwi (2019) FORMULASI FAST DISINTEGRATING TABLET CAPTOPRIL MENGGUNAKAN KOMBINASI SUPERDISINTEGRANT CROSCARMELLOSE SODIUM DAN CROSPOVIDONE. Tesis thesis, Universtitas Setia Budi.

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Abstract

YULIANA, ED., 2019, FORMULATION OF FAST DISINTEGRATING CAPTOPRIL TABLET USING COMBINATIONS SUPERDISINTEGRANT CROSSCARMELLOSE SODIUM AND CROSPOVIDONE Captopril is intended to fast disintegrating tablets disintegrates in the mouth when in contact with saliva in less than 1 minute and are expected to accelerate the therapeutic effect of the drug. This research aims to determine the effect of the combination of superdisintegrant croscarmellose sodium and crospovidone on fast disintegrating captopril tablets on physical quality and the dissolution profile, and get a comparison of the combination of superdisintegrant croscarmellose sodium and crospovidone so that the best form of fast disintegrating captopril tablet is obtained. This study formulated captopril made by fast disintegrating tablets with direct compression method with variations in crosscarmellose sodium and crospovidone concentration with the ratio of 0: 100%; 75: 25%; 50: 50%; 25: 75%; 100: 0%. Tests conducted to determine the physical quality of fast disintegrating captopril tablets are uniformity of weight, uniformity of content, hardness, friability, wetting time, disintegration time (in vivo & in vitro) were tested, and dissolution. Data which had been obtained analyzed statistically by KolmogorovSmirnov test to test the distribution of data, if the normal distribution of data is analyzed by one-way analysis of varance test (ANOVA) with confidence interval 95%. Based on the research results, the combination of superdisintegrant croscarmellose sodium and crospovidone shows that the combination of superdisintegrant croscarmellose sodium high and crospovidone low can reduce hardness, friability, wetting time and disintegration time, so the dissolution profile of fast disintegrating captopril tablets increases and combination with the composition of croscarmellose sodium 75% : crospovidone 25% is able to provide a fast disintegration time of 24.50 seconds. Key words: fast disintegrating tablet, captopril, croscarmellose sodium, crospovidone.

Item Type:	Thesis (Tesis)
Uncontrolled Keywords:	fast disintegrating tablet, captopril, croscarmellose sodium, crospovidone.
Subjects:	R Medicine > R Medicine (General)
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Tifany Nur Arfiana
Date Deposited:	17 Mar 2022 07:54
Last Modified:	17 Mar 2022 07:54
URI:	http://repo.setiabudi.ac.id/id/eprint/4503

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