OPTIMASI FORMULA SNEDDS LENDIR BEKICOT (Achatina fulica) MENGGUNAKAN KOMPONEN CAPRYOL® 90, KOLLIPHOR® EL, DAN PEG 400 DENGAN METODE D-Optimal

Sari, Putri Mutia (2020) OPTIMASI FORMULA SNEDDS LENDIR BEKICOT (Achatina fulica) MENGGUNAKAN KOMPONEN CAPRYOL® 90, KOLLIPHOR® EL, DAN PEG 400 DENGAN METODE D-Optimal. Skripsi thesis, Universitas Setia Budi.

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Abstract

Snails (Achatina fulica) produce mucus containing achasin-AF and mytimacin-AF proteins with antibacterial activity against Streptococcus aureus and Escherichia coli. Achasin proteins has molecular weights of 83.67 kDa and mytimacin-AF proteins has moleculer weights of 9,7 kDa. Protein has unstable properties. The formulation SNE (self-nano emulsion) method is a stable delivery system. The purpose of this study isto formulate snail mucus protein into SNE and optimize SNE formulation comprising Capryol® 90, Kolliphor® EL and PEG 400. The hydrophobic ion pairing technique isused to obtain snail mucus protein. This study used the method D-Optimal mixture design with combination of capryol® 90, kolliphor® EL and PEG 400 and tested the characterization of emulsification time, the determination of drug loading, and percent transmittance. The result showed that snail mucus has been incorporated in SNE by hydrophonic on pairing method. The selected optimum formula of SNEDDS snail mucus selected was Capryol® 90 for 1 parts, Kolliphor® EL for 5 parts, and PEG 400 for 4 parts with emulsification time 25,53 seconds ,percent transmittan 84,19% and drug loading is more than 10 %. Keywords: Achatina fulica, hydrophobic ion pairing, SNEDDS, D-Optima

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	Achatina fulica, hydrophobic ion pairing, SNEDDS, D-Optima
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Tifany Nur Arfiana
Date Deposited:	17 Mar 2022 07:53
Last Modified:	17 Mar 2022 07:53
URI:	http://repo.setiabudi.ac.id/id/eprint/4602

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