KAJIAN LITERATUR AKTIVITAS SITOTOKSIK Garcinia Sp. DAN PENGARUHNYA TERHADAP EKSPRESI PROTEIN PADA KULTUR SEL KANKER PAYUDARA

Amanda, Olyvia Rennisa (2020) KAJIAN LITERATUR AKTIVITAS SITOTOKSIK Garcinia Sp. DAN PENGARUHNYA TERHADAP EKSPRESI PROTEIN PADA KULTUR SEL KANKER PAYUDARA. Skripsi thesis, Universitas Setia Budi.

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Abstract

Breast cancer is a cancer that attacks the epithelial tissue of the breast, the mucous membrane and glands so that breast cancer is classified as carcinoma. The causes of breast cancer are very diverse, including damage to DNA that causes genetic mutations. Mangosteen leaves contain flavonoid compounds, tannins and saponins. This study aims to determine the cytotoxic activity of Garcinia Sp. Against the study of breast cancer cell culture and determine its effect on the expression of breast cancer cell culture protein. The research began with study literature. The study of cytotoxic activity was carried out using the literature review study method to determine the cytotoxic activity of Garcinia Sp. and its effect on breast cancer cell culture protein expression. The results of the study of cytotoxic activity showed that Garcinia Sp. has cytotoxic activity in T47d and MCF-7 cancer cell cultures with IC50 value parameters. The results of the study of the effect of protein expression on cancer cells indicate that Garcinia Sp, especially in mangosteen plants can increase some protein expression such as Bax / Bcl-2, caspase-3, caspase-9 and P21 so that triggers apoptosis in various cancer cells. Keywords : Cytotoxic, Garcinia Sp, Breast Cancer, Protein Expression

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	Cytotoxic, Garcinia Sp, Breast Cancer, Protein Expression
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Tifany Nur Arfiana
Date Deposited:	17 Mar 2022 07:52
Last Modified:	17 Mar 2022 07:52
URI:	http://repo.setiabudi.ac.id/id/eprint/4609

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