Irfani, Mohamad Andry (2020) STUDI LITERATUR UJI AKTIVITAS EKSTRAK KASAR ENZIM FIBRINOLITIK DARI BAKTERI Bacillus subtilis PADA GALUR YANG BERBEDA MENGGUNAKAN METODE PLAT FIBRIN SECARA In Vitro. Skripsi thesis, Universitas Setia Budi.
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Abstract
Thrombosis is a condition in which the formation of an intravascular blood clot caused by excessive fibrin formation. Abnormalities caused by thrombosis can be treated with fibrinolytic. One of the dibrinolytic sources is Bacillus subtilis. The purpose of this study is to know about the activity of coarse extracts of fibrinolytic enzymes as a fibrinolytic therapy derived from Bacillus subtilis with different strains. This research begins identification of fibrinolytic coding genes and then identification of Gram staining, test for blood, catalase test and coagulant. Further extraction of enzymes by centrifugation, continuing the breakdown of cells by sonication. Enzyme purification, determination of levels and test of acarity is done by literature study. The journal Search for Literary studies uses Google Scholer as a search engine for international journal criteria contained in Elsevier and NCBI and a National Journal of Synta. Bacillus Subtilis has beta activity of hemolysis, Gram-positive, has catalase enzymes and coagulase. Test gene in silico there is a gene Aprn coding nattokinase. Isolation of enzymes from Bacillus subtilis ATCC 3366 obtained results 15 ml. Determination of levels based on literary studies of various strains of Bacillus subtilis states, the best activity test of Bacillus subtilis ICTF-1 with specific activity 8645 U/mg. The results show that the bacteria of Bacillus subtilis with different strains has great potential as a fibrinolytic agent. Keywords: Thrombosis, Bacillus Subtilis, Fibrinolytic, fibrin plate,
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | Thrombosis, Bacillus Subtilis, Fibrinolytic, fibrin plate, |
| Subjects: | R Medicine > RS Pharmacy and materia medica |
| Divisions: | Fakultas Farmasi > Prodi S1 Farmasi |
| Depositing User: | Tifany Nur Arfiana |
| Date Deposited: | 29 Mar 2022 07:55 |
| Last Modified: | 29 Mar 2022 07:55 |
| URI: | http://repo.setiabudi.ac.id/id/eprint/4660 |
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