Wijayanti, Ludy Mustika (2020) PENGARUH VARIASI KONSENTRASI HPMC K4M TERHADAP MUTU FISIK NANOSTRUCTURED LIPID CARRIERS (NLC) RESVERATROL BERBASIS GEL DAN STUDI DESKRIPTIF TERHADAP PELEPASAN OBAT SERTA AKTIVITAS ANTIOKSIDAN SEDIAAN TOPIKAL. Skripsi thesis, Universitas Setia Budi.
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Abstract
Resveratrol is a natural polyphenol antioxidant compound derived from stibilene which has antioxidant power and has strong potential as a free radical. Resveratrol can be made in the Nano Lipid Carriers (NLC) system because resveratrol has low water solubility so that it can affect its bioavailability. This study aims to determine the effect of variations in the concentration of HPMC K4M on the physical quality of gel-based resveratrol NLC and its effect on the release of drugs and antioxidants of topical preparations based on descriptive studies. Resveratrol NLC formula with various concentrations of HPMC K4M, namely 4%, 6%, 8%, and 10% were used to determine the good physical qualities of the preparation. Resveratrol NLC was characterized by parameters of particle size, zeta potential, polydispers index, and absorption efficiency, and gel-based resveratrol NLC was subjected to physical quality tests including organoleptic, homogeneity, pH, viscosity, adhesion, dispersibility, and a descriptive study of drug release, and antioxidant activity. The results showed variations in the concentration of HPMC affect the physical quality of gel preparations, where the higher the concentration of HPMC used, the higher the viscosity resulting in the lower power spread, the sticking power is stronger and causes active substances to be retained so that there is a decrease in drug release. Antioxidant activity is low due to an increase in HPMC concentration. Keywords: NLC resveratrol, HPMC K4M, gel
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | NLC resveratrol, HPMC K4M, gel |
| Subjects: | R Medicine > RS Pharmacy and materia medica |
| Divisions: | Fakultas Farmasi > Prodi S1 Farmasi |
| Depositing User: | Tifany Nur Arfiana |
| Date Deposited: | 29 Mar 2022 07:55 |
| Last Modified: | 29 Mar 2022 07:55 |
| URI: | http://repo.setiabudi.ac.id/id/eprint/4683 |
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