FORMULASI SEDIAAN EMULGEL DARI EKSTRAK ETANOL BIJI KEDELAI (Glycine max (L.) Merril) SEBAGAI ANTIOKSIDAN DENGAN VARIASI KONSENTRASI KARBOPOL

Riandwenty, Izha Asviota (2020) FORMULASI SEDIAAN EMULGEL DARI EKSTRAK ETANOL BIJI KEDELAI (Glycine max (L.) Merril) SEBAGAI ANTIOKSIDAN DENGAN VARIASI KONSENTRASI KARBOPOL. Skripsi thesis, Universitas Setia Budi.

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Abstract

Soybean seeds were known to contain flavonoid compounds which can be used as antioxidants. This study was aimed to determine the effect of variations in the concentration of carbopol on stability and activity antioxidant of preparation emulgel of soybean seeds extract, and knowing formulations emulgel of soybean seeds extract which has the effect of antioxidants and stability are good. This research was conducted in several stages, namely soybean seeds extracted by maceration method, using ethanol solvent then emulgel preparations were made with a variation of carbopol content 0, 5 %; 1%; 1.5%. Formula 1 to 3 were contained 5% extract ethanol seeds of soybean and formula 4 wass a control negative. Physical quality of emulgel were done by testing the organoleptic, homogeneity, viscosity, the power spread, the power sticky, pH, and stability. Antioxidant activity was tested by DPPH (1, 1 -Diphenyl-2- Picrylhydrazyl), using a spectrophotometer UV-Vis at wavelength of 516 nm. Absorbance data was used to measure IC50. The results of the data were analyzed using apropriate statistic. Results of the study showed that the increase in the levels of carbopol on emulgel of soybean seed extract could effect on the physical quality ie an increase in viscosity, an increase in power attached, and a decrease in power spread, but did not affect the homogeneity, pH, and antioxidant activity. Emulgel of soybean seeds extract had antioxidant activity with IC50 of 11,954 ppm until 17,055 ppm. The emulgel formula of soybean seed extract which had the best stability and antioxidant effect was formula 2 with a carbopol concentration of 1%. Keywords : antioxidant, radical free DPPH, soybean seed extract, emulgel, Carbopol 940

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	antioxidant, radical free DPPH, soybean seed extract, emulgel, Carbopol 940
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Tifany Nur Arfiana
Date Deposited:	09 Jun 2022 03:27
Last Modified:	09 Jun 2022 03:27
URI:	http://repo.setiabudi.ac.id/id/eprint/4742

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