Febrianti, Alien Prisma (2020) UJI AKTIVITAS ANTI AGING KRIM EKSTRAK ETANOL KULIT BUAH RAMBUTAN (Nephelium lappaceum L.) PADA KULIT PUNGGUNG KELINCI NEW ZEALAND YANG DIPAPAR SINAR UV-A. Skripsi thesis, Universitas Setia Budi.
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Abstract
Sunlight exposure to our skin, of which we’re accustomed to in our daily life, actually affect the speed of our skin aging. The effect of UV light, of which it is a source of free radicals, can be prevented with antioxidant compound. Antioxidant compound is an antiradical compound that could neutralize reactive free radicals and turn it into its relatively more stable non-reactive state so it’s able to protect the cells from the dangerous effects of free radicals. Rambutan fruit skin contains high level of flavonoid, a kind of antioxidant compound. The easiest mechanism to administer the extract is to make it into cream based cosmetic. This research is done to ascertain whether or not rambutan skin ethanol extract cream could endow anti-aging effect in vivo to UV-A exposed New Zealand rabbit. Rambutan (Nephelium lappaceum L.) extract processed into cream, before then tested for its physical quality and stability. The anti-aging activity test is done to 4 rabbits, of which their back fur shaved and the inducted to UV-A exposure, 6 hours a day for 2 weeks. The back hide of the rabbit will then administered with rambutan extract cream of varying concentration: 3%, 6%, and 9%, with negative control. The administration will be done for 28 days and measured using Skin Analyzer every week for four weeks. The factors observed in this experiments are collagen percentage, skin moisture, elasticity, and pore width. Physical quality test resulted to F1, F2, F3, and F4 all passed the organoleptic, homogeneity, pH, viscosity, and spread power condition. Stability test for F1, F2, F3, and F4 resulted in them qualifying its organoleptic and viscosity condition. Primary safety test shows that the rambutan skin extract cream does mildly irritate the skin, whilst ocular irritation test on the cream resulted in no irritation. The research shows that rambutan skin extract cream with 3% concentration gave the most effective anti-aging effect. Keywords: rambutan extract, anti-aging activity, cream, safety test
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | rambutan extract, anti-aging activity, cream, safety test |
| Subjects: | R Medicine > RS Pharmacy and materia medica |
| Divisions: | Fakultas Farmasi > Prodi S1 Farmasi |
| Depositing User: | Tifany Nur Arfiana |
| Date Deposited: | 09 Jun 2022 03:28 |
| Last Modified: | 09 Jun 2022 03:28 |
| URI: | http://repo.setiabudi.ac.id/id/eprint/4771 |
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