UJI ANTIINFLAMASI EKSTRAK ETANOL DAUN DUWET (Syzygium cumini L SKEELS) DAN UJI HISTOPATOLOGI TERHADAP LAMBUNG TIKUS WISTAR (Rattus norvegicus L) SECARA IN VIVO

Hanifan, Dhiya (2020) UJI ANTIINFLAMASI EKSTRAK ETANOL DAUN DUWET (Syzygium cumini L SKEELS) DAN UJI HISTOPATOLOGI TERHADAP LAMBUNG TIKUS WISTAR (Rattus norvegicus L) SECARA IN VIVO. Skripsi thesis, Universitas Setia Budi.

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Abstract

The use of NSAID drug therapy has side effects that can adversely affect the body's biological functions such as the liver, digestive tract and other vital organs. Syzygium cumini L. Skeels or duwet plants which contain several compounds including alkaloids, flavonoids, tannins, and saponin. The purpose of this study was to determine the dose of duwet leaf extract has anti-inflammatory effects and side effects on the stomach of white rats in histopathological testing in vivo. This research was conducted using 25 male wistar white rats divided into 5 groups consisting of 0,5 % CMC group (negative control), diclofenac sodium (positive control), and dose of ethanol extract of duwet leaves 50 mg / kg BW, dose ethanol extract of duwet leaves 100 mg / kg BW, and dose ethanol extract of duwet leaves 200 mg / kg BW given orally after induction with carrageenan. The edema volume measurement was performed at minute (60,120,180,240,300, and 360). The results of edema volume calculated by AUC and percent of anti-inflammatory power were analyzed statistically by Shapiro-wilk ,One-way ANOVA, and post hoc LSD. The results of this study the ethanol extract of duwet leaves 100 mg / kg BW, and 200 mg / kg BW has an anti-inflammatory effect with a positive control ratio. The closest result to positive control was the administration of ethanol extract of duwet leaf 200 mg / kg BW. Histopathological test results showed that the ethanol extract of duwet leaf ethanol extract of duwet leaves 50mg / kg BW, 100 mg / kg BW, and 200 mg / kg BW were safe for the stomach. Keywords: Duwet leaf, anti-inflammatory, histopathology, safe stomach

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	Duwet leaf, anti-inflammatory, histopathology, safe stomach
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Tifany Nur Arfiana
Date Deposited:	09 Jun 2022 03:28
Last Modified:	09 Jun 2022 03:28
URI:	http://repo.setiabudi.ac.id/id/eprint/4784

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