Utami, Firda (2020) FORMULASI EMULGEL PIROXICAM DENGAN PROPILENGLIKOL DAN MENTOL SEBAGAI PENETRATION ENHANCERS SERTA UJI ANTIINFLAMASI PADA TIKUS PUTIH JANTAN (Rattus novergicus). Skripsi thesis, Universitas Setia Budi.
![[img]](http://repo.setiabudi.ac.id/style/images/fileicons/text.png) |
Text
INTISARI DAN ABSTRAK.pdf Download (36kB) |
|
Text
FORM PERNYATAAN PUBIKASI.pdf Download (116kB) |
|
Text
BAB I.pdf Download (387kB) |
|
Text
BAB II.pdf Restricted to Repository staff only Download (412kB) | Request a copy |
|
Text
BAB III.pdf Restricted to Repository staff only Download (109kB) | Request a copy |
|
Text
BAB IV.pdf Restricted to Repository staff only Download (372kB) | Request a copy |
|
Text
BAB V.pdf Download (1MB) |
Abstract
Piroxicam is a nonsteroidal anti-inflammatory drugs that has good activity as an antiinflamatory effects. Its mechanism of action is thought to be through inhibition of COX-1 and COX-2, key enzimes in the biosynthesis of prostaglandin. The major problem associated with transdermal drug delivery is barrier properties of the stratum corneum, these permeation problems can be minimized by use of chemical penetration enhacer. The present study aims to develop piroxicam emulgel (PE) as transdermal delivery system in order to overcome the skin erithema in transdermal drug delivery. The experiments were performed using white rats. The rats were subcutaneously radiated UVB rays for 24 hours then followed by giving an emulgel contains piroxicam. The rats were randomized into 5 groups, emulgel were applied to group 1 (formula 4), PE comprising 5% menthol group 2 (formula 1), PE comprising 1,5% menthol and 5% propylene glycol group 3 (formula 2), PE comprising 10% propylene glycol group 4 (formula 3) and Pirofel®gel piroxicam group 5 to the derms of rats. The erithema observed 72 hours, data were analyzed statistically using Two Way ANOVA method. In this study, PE showed significantly effective for reducing erithema by using penetration enhancer in formulation with high physical stability. An emulgel has the ideal antiinflamatory activity is a Formula 3, propylen glicol 10% be able to healing affecting extra-cellular lipid components, which encourages diffusion process and facilities a drug to the skin. Keywords: Piroxicam, penetration enhancers, Emulgel, antiinflamatory
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | Piroxicam, penetration enhancers, Emulgel, antiinflamatory |
| Subjects: | R Medicine > RS Pharmacy and materia medica |
| Divisions: | Fakultas Farmasi > Prodi S1 Farmasi |
| Depositing User: | Tifany Nur Arfiana |
| Date Deposited: | 09 Jun 2022 03:29 |
| Last Modified: | 09 Jun 2022 03:29 |
| URI: | http://repo.setiabudi.ac.id/id/eprint/4794 |
Actions (login required)
 |
View Item |
