UJI AKTIVITAS ANTI-AGING SECARA IN VIVO DARI SEDIAAN EMULGEL MINYAK ATSIRI DAUN JERUK PURUT (Citrus hystrix DC)

Hartono, Dannys (2020) UJI AKTIVITAS ANTI-AGING SECARA IN VIVO DARI SEDIAAN EMULGEL MINYAK ATSIRI DAUN JERUK PURUT (Citrus hystrix DC). Skripsi thesis, Universitas Setia Budi.

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Abstract

UV A radiation can penetrate dermis so the skin becomes wrinkled and causes premature aging. Premature aging can be prevented by using anti-aging products. Kaffir lime leaf essential oil (Citrus hystrix DC) has antioxidant activity to protect skin from cell damage caused by free radicals. This research was conducted to determine activity of emulgel from kaffir lime leaf essential oil as anti-aging in vivo. Kaffir lime leaf essential oil was characterized and tested its antioxidant activity, then formulated into emulgel with concentrations of 10, 15, and 20%. Emulgel was tested for physical quality and stability as well as primary irritation test. Anti-aging activity test used 5 rabbits that had their backs shaved and induced UV A for 2 weeks, then they were given treatment for 30 days. Percent pigment, collagen, elasticity, and moisture were observed using skin analyzer. The characterization are accordance with Certificate of Analysis. Antioxidant activity test resulted IC50 value is 22,42 ppm. Kaffir lime leaf essential oil can be formulated into emulgel that has good physical quality and stability. The primary irritation test showed emulgel was not irritating. Anti-aging activity test showed emulgel from kaffir lime leaf essential oil with concentration of 20% gave optimal anti-aging effect. Keywords: kaffir lime leaf essential oil, emulgel, anti-aging activity, skin analyzer

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	kaffir lime leaf essential oil, emulgel, anti-aging activity, skin analyzer
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Tifany Nur Arfiana
Date Deposited:	09 Jun 2022 03:29
Last Modified:	09 Jun 2022 03:29
URI:	http://repo.setiabudi.ac.id/id/eprint/4813

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