FORMULASI DAN UJI AKTIVITAS ANTIOKSIDAN DENGAN METODE DPPH DARI SEDIAAN LOTION NARINGENIN KOMBINASI ASAM STEARAT DAN SETIL ALKOHOL

Yuliana, Sinta (2020) FORMULASI DAN UJI AKTIVITAS ANTIOKSIDAN DENGAN METODE DPPH DARI SEDIAAN LOTION NARINGENIN KOMBINASI ASAM STEARAT DAN SETIL ALKOHOL. Skripsi thesis, Universitas Setia Budi.

	Text INTISARI DAN ABSTRACT (1).pdf Download (13kB)
	Text form_pernyataan_publikasi (SINTA YULIANA) (1).pdf Download (254kB)
	Text BAB I (16).pdf Download (1MB)
	Text BAB II (24).pdf Restricted to Repository staff only Download (519kB) | Request a copy
	Text BAB III (22).pdf Restricted to Repository staff only Download (304kB) | Request a copy
	Text BAB IV (24).pdf Restricted to Repository staff only Download (445kB) | Request a copy
	Text BAB V (17).pdf Restricted to Repository staff only Download (184kB) | Request a copy
	Text DAFTAR PUSTAKA (19).pdf Download (240kB)
	Text LAMPIRAN (14).pdf Download (1MB)

Abstract

Naringenin is a flavonoid compound that has anti-inflammatory, anticancer, antiantherogenic, antifibrogenic, and antioxidant activities. Flavonoids also act as antioxidants to ward off free radicals found in the free air, which causes premature aging, wrinkled skin, dullness, and so on. This study aims to determine the influence of stearic acid variation and alcohol setil on the physical quality and activity of naringenin lotion preparations seen from its IC50 value using the DPPH method (1,1-diphenyl-2-picryhidrazyl). Physical quality test of naringenin lotion formula made into 3 formulas with a concentration of 0.4 in 100 grams is carried out with organoleptic parameters, homogeneity, emulsion type, scatter power, adhesion, pH, and viscosity. To test the stability of naringenin lotion with a combination of stearic acid and alcohol, it is done by looking at the parameters of scatter power, adhesion, pH, and viscosity, which are seen every week. Determination of IC50 value for antioxidant test using DPPH method (1,1-diphenyl-2-picryhidrazyl) using UV-Vis spectrophotometer. Physical and antioxidant quality test results are statistically analyzed using One Way ANOVA. Naringenin lotions with a combination of stearic acid and alcohol can make a significant difference to physical quality tests after stability that include organoleptic testing, pH, viscosity, dissorientation, and adhesion. For homogeneity test and emulsion type produces good results in each formula. The best formula when viewed from physical quality test and IC50 value, namely formula 3 with a combination of stearic acid and alcohol setil (4.2 : 5.8) and got IC50 value of 52.74 ppm, including strong category and IC50 value for pure naringenin isolate of 20.83 ppm, including very strong category. Key words : naringenin, stearic acid, alcohol levels, antioxidant activity tests, and physical quality test preparations.

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	naringenin, stearic acid, alcohol levels, antioxidant activity tests, and physical quality test preparations.
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Tifany Nur Arfiana
Date Deposited:	16 Jun 2022 07:20
Last Modified:	16 Jun 2022 07:20
URI:	http://repo.setiabudi.ac.id/id/eprint/4878

Actions (login required)

View Item