UJI AKTIVITAS ANTIDIABETES RESISTENSI INSULIN EKSTRAK WORTEL (Daucus carota L.) PADA MENCIT JANTAN GALUR SWISS

Saputro, Yohanes Nugroho Dwi (2020) UJI AKTIVITAS ANTIDIABETES RESISTENSI INSULIN EKSTRAK WORTEL (Daucus carota L.) PADA MENCIT JANTAN GALUR SWISS. Skripsi thesis, Universitas Setia Budi.

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Abstract

Carrot plant (Daucus carota L.) is a plant that is widely distributed throughout the world. From this plant contains a compound in the form of lycopene which acts as an antidiabetic agent. This study aims to prove that the treatment induces hyperglycemic and insulin resistance in Swiss male mice. A total of 25 male mice were then divided into 5 treatment groups. Group I (negative group CMC Na 0.5%); group II (metformin positive control); group III (carrot extract dose of 4.44 g / kg BW of mice); group IV (carrot extract dose of 8.92 g / kg BW of mice); and group V (carrot extract dose of 17.88 g / kg body weight of mice). After 46 days of treatment, the blood sugar data of the tested animals were analyzed using the SPSS one way ANOVA method followed by LSD and Duncan tests. The effect of insulin tolerance test treatment on blood glucose levels was determined by statistically comparing blood glucose levels before and after treatment. Insulin resistance was determined by comparing the hypoglycemic effect of metformin 0.052 g / kgBW with the natural substance group. The results of the study concluded that the treatment of carrot extract at a dose of 8.92 g / kgBB for 14 days was able to reduce blood glucose levels of Swiss male mice to 128.60 mg / dL (p <0.05). Key words : antidiabetic, carrot extract (Daucus carota L.), insulin resistance

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	antidiabetic, carrot extract (Daucus carota L.), insulin resistance
Subjects:	R Medicine > R Medicine (General)
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Tifany Nur Arfiana
Date Deposited:	16 Jun 2022 07:20
Last Modified:	16 Jun 2022 07:20
URI:	http://repo.setiabudi.ac.id/id/eprint/4887

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