AKTIVITAS ANTIPIRETIK EKSTRAK ETANOL DAUN KEMBANG BUGANG (Clerodendrum calamitosum L) PADA TIKUS PUTIH JANTAN GALUR WISTAR DENGAN INDUKSI VAKSIN DPT-HB-HIB

KHOLIDIA, Ais Korbindra (2018) AKTIVITAS ANTIPIRETIK EKSTRAK ETANOL DAUN KEMBANG BUGANG (Clerodendrum calamitosum L) PADA TIKUS PUTIH JANTAN GALUR WISTAR DENGAN INDUKSI VAKSIN DPT-HB-HIB. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Fever is a condition where the body temperature above normal temperature of 37.5ºC. The purpose of this study was to determine the antipyretic activity of ethanol extract of kembang bugang leaf and to determine the dose of extract ethanol of kembang bugang leaf which have the most optimal antipyretic activity by method of DPT- HB-HIB vaccine-induced. Kembang bugang leaf was extracted by maceration method using ethanol 96%. The antipyretic test was performed on 25 rats divided into 5 groups: fever control (CMC-Na), antipyretic control (Paracetamol 45 mg/kg BW), ethanol extracts of kembang bugang leaf 30,85 mg, 61,75 mg and 123,5 mg/kg BW, each group was DPT-HB-HIB vaccine-induced prior to treatment. Rectal temperature measurements were performed before vaccine-induced, 4 hour after vaccine-induced, and 30 minute to 180 minute after treatment. The results showed that ethanol extract of kembang bugang leaf doses of 30,85, 61,75, and 123,5 mg/kg BW had antipyretic activity of DPT-HB-HIB vaccine method. Ethanol extract of kembang bugang leaf dose of 61,75 mg/kg BB had the most optimal antipyretic activity. The content which expected have antipyretic effect was flavonoid. Keywords : Antipyretic, extract of kembang bugang leaf, DPT-HB-HIB vaccine-induced.

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	Antipyretic, extract of kembang bugang leaf, DPT-HB-HIB vaccine-induced.
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Tifany Nur Arfiana
Date Deposited:	22 Feb 2019 07:16
Last Modified:	22 Feb 2019 07:16
URI:	http://repo.setiabudi.ac.id/id/eprint/49

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