AKTIVITAS ANTIDEPRESAN EKSTRAK ETANOL KAYU SECANG (Caesalpinia sappan L.) DAN PENGARUHNYA TERHADAP KADAR GLUKOSA DARAH PADA MENCIT PUTIH JANTAN YANG DIINDUKSI FORCED SWIM TEST

Sanchika, Anindhita Ayu (2020) AKTIVITAS ANTIDEPRESAN EKSTRAK ETANOL KAYU SECANG (Caesalpinia sappan L.) DAN PENGARUHNYA TERHADAP KADAR GLUKOSA DARAH PADA MENCIT PUTIH JANTAN YANG DIINDUKSI FORCED SWIM TEST. Skripsi thesis, Universitas Setia Budi.

	Text Abstrak (4).pdf Download (38kB)
	Text Anindhita Ayu Sanchika_Turnitin.pdf Download (22kB)
	Text form pernyataan publikasi - Anindhita.pdf Download (202kB)
	Text BAB I (44).pdf Download (472kB)
	Text BAB II (59).pdf Restricted to Repository staff only Download (343kB) | Request a copy
	Text BAB III (58).pdf Restricted to Repository staff only Download (211kB) | Request a copy
	Text BAB IV (59).pdf Restricted to Repository staff only Download (416kB) | Request a copy
	Text BAB V_Kesimpulan.pdf Restricted to Repository staff only Download (26kB) | Request a copy
	Text Daftar Pustaka (47).pdf Download (47kB)
	Text Lampiran (48).pdf Download (1MB)

Abstract

Depressive disorder is a serious medical disorder that has disorders of the neurotransmitters norepinephrine, serotonin and dopamine. Depression causes different behaviors in test animals, such as silence or immobility, decreased hygiene or grooming behavior. Depression also causes an overproduction of cortisol, leading to high blood glucose levels. The brazilin compound purified from secang wood (Caesalpinia sappan L.) has the potential to be an antidepressant. The purpose of this study was to determine the antidepressant activity of secang wood ethanol extract and its effect on blood glucose levels in mice induced by forced swim tests. Male mice were adapted for 7 days and then depressed using the forced swim test method for 11 days with a duration of 5 minutes. The doses used in this study were 10.69; 21.38 and 42.74 mg/KgBB. The positive control used was fluoxetin 0.052 mg/20 gBB mice and the negative control used was 0.5% Na CMC. Mice were measured for imobility time using the forced swim test method, the duration of grooming with a sucrose splash test and blood glucose levels using a glucometer. The results showed that the ethanol extract of secang wood with a dose of 10,69; 21,38 and 42,76 mg /KgBB were able to significantly reduce time immobility by 42,56; 44,43 and 50,03% and the decrease in blood sugar levels respectively 12,43; 16,84 and 24,71%. The duration of the show shows negative immobility time values. The conclusion of this study is that the induction of FST leads to depression, increased IT, decreased treatment and increased blood glucose levels. The effective dose for reducing depression was at a dose of 10,69 mg / KgBB, while the effective dose for reducing blood glucose levels was at a dose of 4,76 mg / KgBB. Keywords: antidepressant, secang wood extract, blood glucose, imobility time, forced swimming test

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	antidepressant, secang wood extract, blood glucose, imobility time, forced swimming test
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Tifany Nur Arfiana
Date Deposited:	21 Jul 2022 03:57
Last Modified:	21 Jul 2022 03:57
URI:	http://repo.setiabudi.ac.id/id/eprint/4935

Actions (login required)

View Item