Suryawan, Fatwa Aji (2021) UJI AKTIVITAS ANTIDEPRESAN MINYAK ATSIRI DAUN SELASIH PADA MENCIT SWISS WEBSTER JANTAN. Skripsi thesis, Universitas Setia Budi.
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Abstract
Depression is defined as a feeling disorder characterized by a dysphoric effect (loss of excitement / arousal) accompanied by other symptoms, such as sleep disturbances, decreased appetite accompanied by slowed movement and bodily functions. Basil leaves contain several active substances, one of which is eugenol, which is known to have an antidepressant effect. The mechanism of eugenol content in providing an antidepressant effect is by inhibiting the Mono Amine Oxidase A and B enzymes. This study aims to determine the effectiveness of essential oil of basil leaves as an antidepressant in male Swiss Webster mice and to determine its effective dosage. The antidepressant research used the forced swim test method by observing the immobility time of mice. The test animals used 15 male white mice which were divided into 5 groups, namely the sick control group (negative control) using 0.5% CMCNa, the healthy control group (positive control) using amithriptyllin, and the essential oil emulsion group with 3 variations of doses (dose 1 is 11.9 mg / kg BW, dose 2 is 23.8 mg / kg BW, and dose 3 is 47.6 mg / kg BW). The test animals were induced with depression by immersion in a forced swim test for 10 days, then after induction they were treated until the 18th day. The immobility time of mice was calculated on day 1; 10th and 18th. The results showed that essential oil doses of 11.9 mg / kg BW, 23.8 mg / kg BW, and 47.8 mg / kg BW were able to reduce depression in male white Swiss Webster mice by seeing a patameter immobility time in mice. The effective dose in reducing depression in mice was 23.8 mg / kg BW. Key words: basil, essential oil, antidepressant, immobility.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | basil, essential oil, antidepressant, immobility. |
| Subjects: | R Medicine > RS Pharmacy and materia medica |
| Divisions: | Fakultas Farmasi > Prodi S1 Farmasi |
| Depositing User: | Tifany Nur Arfiana |
| Date Deposited: | 21 Jul 2022 03:59 |
| Last Modified: | 21 Jul 2022 03:59 |
| URI: | http://repo.setiabudi.ac.id/id/eprint/4973 |
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