UJI EFEK ANTIINFLAMASI EKSTRAK ETANOL KULIT JERUK LEMON (Citrus limon L.) PADA TIKUS PUTIH JANTAN YANG DIINDUKSI KARAGENIN 1%

Wiratmoko, Frendy Ahmad (2021) UJI EFEK ANTIINFLAMASI EKSTRAK ETANOL KULIT JERUK LEMON (Citrus limon L.) PADA TIKUS PUTIH JANTAN YANG DIINDUKSI KARAGENIN 1%. Skripsi thesis, Universitas Setia Budi.

	Text Intisari & Abstrak.pdf Download (37kB)
	Text BAB I.pdf Download (364kB)
	Text BAB II.pdf Restricted to Repository staff only Download (293kB) | Request a copy
	Text BAB III.pdf Restricted to Repository staff only Download (252kB) | Request a copy
	Text BAB IV.pdf Restricted to Repository staff only Download (185kB) | Request a copy
	Text BAB V.pdf Restricted to Repository staff only Download (32kB) | Request a copy
	Text DAFTAR PUSTAKA.pdf Download (144kB)
	Text LAMPIRAN.pdf Download (1MB)
	Text LEMBAR PERNYATAAN PUBLIKASI.pdf Download (153kB)
	Text Surat Keterangan Bebas Plagiasi Universitas Setia Budi.pdf Download (27kB)

Abstract

Inflammation is the body's defense response to the tissue damage. Inflammation can be caused by microorganisms, chemical substances, physical influences and can also be caused by the presence of major diseases. Lemon (Citrus limon L.) has a lot of vitamin C that are used to improve the immune system, antioxcidant, and anti-inflammatory. The purpose of this study was to find out the total flavonoid content in the extract, knowing the anti-inflammatory effect of lemon peel ethanol extract on the legs of carrageenan-induced rats. Lemon peel ethanol extract was obtained by maceration method using ethanol solvent 96%. Total flavonoid levels in extracts determined by UV-Vis spectroscopy. This study used 25 rat test animals and then divided into 5 groups, namely CMC-Na group 0.5%, sodium diclofenac group 4.5 mg/kgBW, extract group dose 100, 150, and 200 mg/kgBW. Rat legs were induced with lamda-carrageenan 1% intraplantically. Measurement of the volume of edema in the legs of mice was carried out every hour for 6 hours. The result of total flavonoid content of lemon peel ethanol extract was 57.2822 mg/L. The results of the in vivo anti-inflammatory test showed that the ethanolic extract of lemon peel had an anti-inflammatory effect because it could reduce the volume of edema in the feet of rats that were artificially inflamed with 1% carrageenin. The effective dose of ethanolic extract of lemon peel to inhibit inflammation in rat feet is a dose of 200 mg/kgBW with a percentage of anti-inflammatory power of 48.82%. Keywords: lemon peel, spectrophotometry UV-Vis, anti-inflammatory

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	lemon peel, spectrophotometry UV-Vis, anti-inflammatory
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Tifany Nur Arfiana
Date Deposited:	21 Jul 2022 03:59
Last Modified:	21 Jul 2022 03:59
URI:	http://repo.setiabudi.ac.id/id/eprint/4980

Actions (login required)

View Item