UJI AKTIVITAS ANTI JERAWAT EMULGEL EKSTRAK DAUN KELOR (Moringa oleifera L) TEHADAP KELINCI PUTIH NEW ZEALAND YANG DIINDUKSI BAKTERI Staphylococcus aureus ATCC 25923

Muzaqi, Moch Mafi Alfi (2021) UJI AKTIVITAS ANTI JERAWAT EMULGEL EKSTRAK DAUN KELOR (Moringa oleifera L) TEHADAP KELINCI PUTIH NEW ZEALAND YANG DIINDUKSI BAKTERI Staphylococcus aureus ATCC 25923. Skripsi thesis, Universitas Setia Budi.

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Abstract

Moringa leaf plant (Moringa oleifera L.) has activity against Staphylococcus aureus because it contains flavonoid compounds, alkaloids, tannins and saponins. Moringa leaves are formulated into emulgel preparations for easier use. The purpose of the study was to determine the anti-acne activity of Moringa leaf extract against Staphylococcus aureus in vivo and to determine the effect of variations in the concentration of Moringa leaf extract on the physical quality of the emulgel. Moringa leaf extract was prepared by maceration method using 96% ethanol as solvent. Emulgel was made using HPMC gelling agent, and using emulsifier tween and span 80 with various concentrations of Moringa leaf extract 12.5%, 15%, and 17.5%. Emulgel was tested for physical quality including organoleptic, homogeneity, pH, spreadability, adhesion, viscosity, and emulsion type. The results of the physical quality test were analyzed using analised Paired t test. Observation of healing healing with loss of erythema, no pus was formed in rabbits. Observation of infection cure was analyzed using one-way ANOVA. Hasil pengujian menunjukkan bahwa emulgel ekstrak daun kelor memiliki mutu fisik yang baik. Variasi konsentrasi ekstrak daun kelor 12,5%, 15%, dan 17,5% memberikan pengaruh pada daya sebar dan viskositas emulgel. Semakin tinggi konsentrasi ekstrak, maka semakin tinggi nilai viskositasnya dan semakin rendah rendah daya sebarnya. Hasil penelitian menunjukkan bahwa emulgel ekstrak daun kelor mempunyai aktivitas antijerawat yang disebabkan oleh bakteri Staphylococcus aureus yang diinduksikan pada kulit punggung kelinci. Formula 3 dengan konsentrasi ekstrak daun kelor 17,5% merupakan formula yang paling optimal dalam penyembuhan jerawat. Key words: acne, Moringa leaf, anti-acne emulgel, Staphylococcus aureus

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	acne, Moringa leaf, anti-acne emulgel, Staphylococcus aureus
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Tifany Nur Arfiana
Date Deposited:	29 Jul 2022 07:46
Last Modified:	29 Jul 2022 07:46
URI:	http://repo.setiabudi.ac.id/id/eprint/5009

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