KAJIAN NETWORK PHARMACOLOGY RIMPANG JAHE ( Zingiber officinale Roscoe ) SEBAGAI IMMUNOMODULATOR

Rachmadani, Muhammad (2021) KAJIAN NETWORK PHARMACOLOGY RIMPANG JAHE ( Zingiber officinale Roscoe ) SEBAGAI IMMUNOMODULATOR. Skripsi thesis, Universitas Setia Budi.

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Abstract

The body's immune system has a function that is to help repair human DNA, prevent infections caused by viruses, bacteria, fungi and other microorganisms, and produce new antibodies to combat foreign bacterial and viral attacks into the body. The task of the immune system is to find and destroy the harmful substances in the human body. Humans have a large number of T cells in their bodies, but with increasing age the number will decrease, which is indicated by the body's vulnerability to disease. Ginger is a plant that is believed to increase immunity. Network pharmacology is a method used to determine the interaction between compounds and proteins. This study aims to determine the compounds that interact with the target protein and to determine the profile of network pharmacology. This research uses cytoscape software in order to know the profile of network pharmacology. The sample used is the chemical content of ginger rhizome taken from the knapsack database and the target protein is obtained from the SuperTarget. The name of the gene that has been obtained is then validated using the Uniprot webserver, after that protein interactions are searched using the web server string. On the string, the interaction results with a combined score of 0.9, then the data is collected into one and tabulated The tabulated data is entered into an application called Cytoscape to view network pharmacology. The network results show that the compounds used do not bind to the target protein used. There are proteins that bind such as BTK protein to LCK, CD40 Ligand to JAK 3, and the ADA protein does not bind to protein because in the selection of targets not all target proteins are taken. Keywords: Zingiber Officinale Roscoe, cytoscape, Immune system, network pharmacology, BTK, LCK, JAK 3, ADA

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	Zingiber Officinale Roscoe, cytoscape, Immune system, network pharmacology, BTK, LCK, JAK 3, ADA
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Tifany Nur Arfiana
Date Deposited:	29 Jul 2022 07:46
Last Modified:	29 Jul 2022 07:46
URI:	http://repo.setiabudi.ac.id/id/eprint/5011

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