FORMULASI DAN OPTIMASI Self-Nanoemulsifying Drug Delivery System (SNEDDS) FUROSEMID DENGAN VARIASI KONSENTRASI TWEEN 80 DAN PEG 400 DENGAN METODE SIMPLEX LATTICE DESIGN (SLD)

Nandita, Sesilia Putri (2021) FORMULASI DAN OPTIMASI Self-Nanoemulsifying Drug Delivery System (SNEDDS) FUROSEMID DENGAN VARIASI KONSENTRASI TWEEN 80 DAN PEG 400 DENGAN METODE SIMPLEX LATTICE DESIGN (SLD). Skripsi thesis, Universitas Setia Budi.

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Abstract

Furosemide is a strong diuretic drug that has low bioavailability. Furosemide can be made Nano emulsion preparations using the SNEDDS method to increase its bioavailability, because SNEDDS is able to form a stable Nano emulsion with a droplet size <200 nm. This study aims to obtain the optimum formula for the variation concentrations of surfactant Tween 80 and cosurfactant PEG 400 according to the characterization test for emulsification time, percent transmittance, and drug loading. The independent variables used in this study were Tween 80 and PEG 400. Seven SNEDDS furosemide formulas from the Simplex Lattice Design (SLD) method were tested for their characterization in the form of emulsification time, percent transmittance, and drug loading. The results of the characterization were optimized using Simplex Lattice Design. The optimum formula was characterized again including emulsification time, percent transmittance, drug loading, particle size, zeta potential and in vitro dissolution, the results were compared with theoretical values and analyzed using the One Sample T-test method. The optimization results obtained Tween of 61.4922% and PEG 400 of 18.5078% with the results of the characterization of the emulsification time of 15.25 seconds, the percentage of transmittance is 94.20%, the drug loading is 50 100.2 ppm, the particle size is 12.18 nm. , the zeta potential was -17.6 mV, and the dissolution rate in vitro reached 106.71% within 15 minutes Keywords : Furosemide, SNEDDS, Tween 80, PEG 400, oleic acid, SLD.

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	Furosemide, SNEDDS, Tween 80, PEG 400, oleic acid, SLD.
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Tifany Nur Arfiana
Date Deposited:	05 Aug 2022 01:36
Last Modified:	05 Aug 2022 01:36
URI:	http://repo.setiabudi.ac.id/id/eprint/5043

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