ISOLASI BAKTERI ENDOFIT DAUN SUKUN (Artocarpus altilis) DAN KAJIAN PUSTAKA AKTIVITASNYA SEBAGAI INHIBITOR ALFA-GLUKOSIDASE

Mawadah, Zulfia Rihadatul (2021) ISOLASI BAKTERI ENDOFIT DAUN SUKUN (Artocarpus altilis) DAN KAJIAN PUSTAKA AKTIVITASNYA SEBAGAI INHIBITOR ALFA-GLUKOSIDASE. Skripsi thesis, Universitas Setia Budi.

	Text I. ABSTRAK.pdf Download (320kB)
	Text II. BAB I.pdf Download (1MB)
	Text III. BAB II.pdf Restricted to Repository staff only Download (858kB) | Request a copy
	Text IV. BAB III.pdf Restricted to Repository staff only Download (816kB) | Request a copy
	Text V. BAB IV.pdf Restricted to Repository staff only Download (978kB) | Request a copy
	Text VI. BAB V.pdf Restricted to Repository staff only Download (315kB) | Request a copy
	Text VII. DAFTAR PUSTAKA.pdf Download (448kB)
	Text VIII. LAMPIRAN.pdf Download (2MB)
	Text Form Pernyataan Publikasi Zulfia.pdf Download (248kB)
	Text Pernyataan Bebas Plagiasi_Zulfia.pdf Download (30kB)

Abstract

Diabetes mellitus (DM) is a metabolic disease characterized by hyperglycemia. The α-glucosidase inhibitor produced by breadfruit leaves can delay the hydrolysis of carbohydrates into glucose, that treating postprandial hyperglycemia in DM. Endophytic bacteria in plant tissues have the potential to produce the same compounds as their host plants. Exploration of endophytic bacteria from plants was carried out to obtain bacteria that produce α-glucosidase inhibitors. The purpose of this study was to isolate endophytic bacteria from breadfruit leaves and to study of its activity as α-glucosidase inhibitors. Isolation of endophytic bacteria was carried out by inoculation of sterilized surface of breadfruit leaves on NA media. Secondary metabolites were obtained by extracting bacterial isolates in YPS liquid media. Bacterial identification was carried out by Gram staining and biochemical test. Identification of flavonoid compounds was carried out by tube test and TLC analysis. The data for α-glucosidase inhibitors endophytic bacteria activity test were obtained ftom literature study. The results obtained 7 isolates of endophytic bacteria from breadfruit leaves with different genus, namely Actinobacillus, Enterobacter, Bordetella, Lactobacillus, 2 isolates belonging to the genus Corynebacterium and one isolate of unknown genus. The results of flavonoid identification showed that genus Actinobacillus and Bordetella were positive for flavonoids. The results of literature study of 4 diabetes medicinal plants revealed that each isolate from several plant had the activity of inhibiting the α-glucosidase enzyme with different strengths. Keywords: antidiabetic, endophytic bacteria, breadfruit leaves, α-glucosidase inhibitor.

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	antidiabetic, endophytic bacteria, breadfruit leaves, α-glucosidase inhibitor.
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Tifany Nur Arfiana
Date Deposited:	05 Aug 2022 01:34
Last Modified:	05 Aug 2022 01:34
URI:	http://repo.setiabudi.ac.id/id/eprint/5059

Actions (login required)

View Item